Community Conversation => Transitioning => Hormone replacement therapy => Topic started by: naa on March 12, 2016, 11:43:53 PM Return to Full Version
Title: Autistic spectrum + estrogen, anti androgens
Post by: naa on March 12, 2016, 11:43:53 PM
Post by: naa on March 12, 2016, 11:43:53 PM
Are there any people here who have been diagnosed as being on the Autistic spectrum? Did you notice any changes in your Autism from anti-androgens or estrogen?
Title: Re: Autistic spectrum + estrogen, anti androgens
Post by: KayXo on March 13, 2016, 12:40:46 AM
Post by: KayXo on March 13, 2016, 12:40:46 AM
Mol Autism. 2014; 5: 46.
"Autism spectrum disorders (ASD) are much more common in males than in females. Molecular alterations within the estrogen receptor (ER) signaling pathway may contribute to the sex difference in ASD, but the extent of such abnormalities in the brain is not known."
"These results, for the first time, provide the evidence of the dysregulation of ERβ and co-factors in the brain of subjects with ASD."
PLoS ONE February 2011 | Volume 6 | Issue 2
"Autism, a pervasive neurodevelopmental disorder manifested by deficits in social behavior and interpersonal communication, and by stereotyped, repetitive behaviors, is inexplicably biased towards males by a ratio of ∼4∶1, with no clear understanding of whether or how the sex hormones may play a role in autism susceptibility. Here, we show that male and female hormones differentially regulate the expression of a novel autism candidate gene, retinoic acid-related orphan receptor-alpha (RORA) in a neuronal cell line, SH-SY5Y. In addition, we demonstrate that RORA transcriptionally regulates aromatase, an enzyme that converts testosterone to estrogen. We further show that aromatase protein is significantly reduced in the frontal cortex of autistic subjects relative to sex- and age-matched controls, and is strongly correlated with RORA protein levels in the brain. These results indicate that RORA has the potential to be under both negative and positive feedback regulation by male and female hormones, respectively, through one of its transcriptional targets, aromatase, and further suggest a mechanism for introducing sex bias in autism."
Estrogen *appears* to be protective and beneficial. :)
"Autism spectrum disorders (ASD) are much more common in males than in females. Molecular alterations within the estrogen receptor (ER) signaling pathway may contribute to the sex difference in ASD, but the extent of such abnormalities in the brain is not known."
"These results, for the first time, provide the evidence of the dysregulation of ERβ and co-factors in the brain of subjects with ASD."
PLoS ONE February 2011 | Volume 6 | Issue 2
"Autism, a pervasive neurodevelopmental disorder manifested by deficits in social behavior and interpersonal communication, and by stereotyped, repetitive behaviors, is inexplicably biased towards males by a ratio of ∼4∶1, with no clear understanding of whether or how the sex hormones may play a role in autism susceptibility. Here, we show that male and female hormones differentially regulate the expression of a novel autism candidate gene, retinoic acid-related orphan receptor-alpha (RORA) in a neuronal cell line, SH-SY5Y. In addition, we demonstrate that RORA transcriptionally regulates aromatase, an enzyme that converts testosterone to estrogen. We further show that aromatase protein is significantly reduced in the frontal cortex of autistic subjects relative to sex- and age-matched controls, and is strongly correlated with RORA protein levels in the brain. These results indicate that RORA has the potential to be under both negative and positive feedback regulation by male and female hormones, respectively, through one of its transcriptional targets, aromatase, and further suggest a mechanism for introducing sex bias in autism."
Estrogen *appears* to be protective and beneficial. :)