Community Conversation => Transitioning => Hormone replacement therapy => Topic started by: EvaLoring on April 22, 2016, 04:59:03 AM Return to Full Version
Title: New to hrt
Post by: EvaLoring on April 22, 2016, 04:59:03 AM
Post by: EvaLoring on April 22, 2016, 04:59:03 AM
Hi i was just wondering that if i take spironolactone with food will i have better effects.Also do yall have any tips for hrt ib general. Thankyou 😊
Title: Re: New to hrt
Post by: Cindy on April 22, 2016, 05:12:56 AM
Post by: Cindy on April 22, 2016, 05:12:56 AM
Just follow what your Doctor tells you. If you are unsure ask them again.
Title: Re: New to hrt
Post by: abd789 on April 22, 2016, 05:40:42 AM
Post by: abd789 on April 22, 2016, 05:40:42 AM
By better effects.... do you mean work better? I dont think so... but it may help you feel better as in side affects
I found that taking e with spiro at the same time made me dizzy and a bit nauseous but that may have happened anyway
I take e in the morning and spiro in the afternoon, both with food
everyone is different
I found that taking e with spiro at the same time made me dizzy and a bit nauseous but that may have happened anyway
I take e in the morning and spiro in the afternoon, both with food
everyone is different
Title: Re: New to hrt
Post by: Riley Skye on April 22, 2016, 09:12:28 AM
Post by: Riley Skye on April 22, 2016, 09:12:28 AM
It really shouldn't matter when you take it. Over time your T levels will drop on it as it did for me. Even if you miss a day it won't harm you either. Just listen to your doctor and in the coming months your T levels will normalize :)
Title: Re: New to hrt
Post by: kelseygal on April 22, 2016, 01:05:44 PM
Post by: kelseygal on April 22, 2016, 01:05:44 PM
Yeah, def go with what your doctor said, or ask them for clarity.
As a personal anecdote, both my doctor and pharmacist went out of there way to tell me to take with food so... I do.
J
As a personal anecdote, both my doctor and pharmacist went out of there way to tell me to take with food so... I do.
J
Title: Re: New to hrt
Post by: Maybebaby56 on April 22, 2016, 02:42:57 PM
Post by: Maybebaby56 on April 22, 2016, 02:42:57 PM
Hi Eva,
The bioavailability of spironolactone is greatly increased when taken with food, so you should try to do that when you can.
Clin Pharmacol Ther. 1986 Nov;40(5):531-6.
Influence of food on the bioavailability of spironolactone.
Overdiek HW, Merkus FW.
Abstract
Nine healthy volunteers received a single oral dose of 200 mg spironolactone, once during fasting conditions and once immediately after a standardized breakfast. Serum concentrations of spironolactone and its metabolites 7 alpha-thiomethylspirolactone, 6 beta-hydroxy-7 alpha-thiomethylspirolactone, and canrenone were determined by HPLC for 24 hours after dosing. By taking spironolactone with food, the mean AUC (0 to 24 hours) of the parent drug increased from 288 +/- 138 (empty stomach) to 493 +/- 105 ng-h/mL. The AUC (0 to 24 hours) of the three metabolites together also increased significantly from 8511 +/- 2062 (empty stomach) to 11219 +/- 2471 ng-hr/mL. The mean percent increase in AUC (0 to 24 hours) of spironolactone when it was given with food, compared with the ingestion on an empty stomach was much more pronounced than the corresponding increase of its metabolites. These observations indicate that food promotes the absorption of spironolactone and possibly decreases its first-pass metabolism.
(AUC = area under the plasma drug concentration-time curve, and reflects the actual body exposure to drug after administration of a dose of the drug and is expressed in mg*h/L.)
With kindness,
Terri
The bioavailability of spironolactone is greatly increased when taken with food, so you should try to do that when you can.
Clin Pharmacol Ther. 1986 Nov;40(5):531-6.
Influence of food on the bioavailability of spironolactone.
Overdiek HW, Merkus FW.
Abstract
Nine healthy volunteers received a single oral dose of 200 mg spironolactone, once during fasting conditions and once immediately after a standardized breakfast. Serum concentrations of spironolactone and its metabolites 7 alpha-thiomethylspirolactone, 6 beta-hydroxy-7 alpha-thiomethylspirolactone, and canrenone were determined by HPLC for 24 hours after dosing. By taking spironolactone with food, the mean AUC (0 to 24 hours) of the parent drug increased from 288 +/- 138 (empty stomach) to 493 +/- 105 ng-h/mL. The AUC (0 to 24 hours) of the three metabolites together also increased significantly from 8511 +/- 2062 (empty stomach) to 11219 +/- 2471 ng-hr/mL. The mean percent increase in AUC (0 to 24 hours) of spironolactone when it was given with food, compared with the ingestion on an empty stomach was much more pronounced than the corresponding increase of its metabolites. These observations indicate that food promotes the absorption of spironolactone and possibly decreases its first-pass metabolism.
(AUC = area under the plasma drug concentration-time curve, and reflects the actual body exposure to drug after administration of a dose of the drug and is expressed in mg*h/L.)
With kindness,
Terri
Title: Re: New to hrt
Post by: JoanneB on April 22, 2016, 07:56:14 PM
Post by: JoanneB on April 22, 2016, 07:56:14 PM
The bottle and directions I get with Spiro says that you just may want to consider taking it with food (To avoid the grumbly tunkie). I Try to do all my pill sub-lingual, as in let them melt under the tongue. It took a bit of doing to get used to Spiro.
So yes, I highly recommend taking Spiro w/Food. A cracker or two, just before or after, is all it takes
So yes, I highly recommend taking Spiro w/Food. A cracker or two, just before or after, is all it takes
Title: Re: New to hrt
Post by: Rachel on April 22, 2016, 08:15:46 PM
Post by: Rachel on April 22, 2016, 08:15:46 PM
Make sure you drink water with Spiro (coffee, soda, fruit drinks, tea does not count as water). You may want to drink 3 quarts of water a day. Also eat salty foods while on spiro.
Relax and breath, starting HRT is exciting and finding some quite time is important.
Congratulations !!
Relax and breath, starting HRT is exciting and finding some quite time is important.
Congratulations !!
Title: Re: New to hrt
Post by: KayXo on April 24, 2016, 11:20:07 AM
Post by: KayXo on April 24, 2016, 11:20:07 AM
Spiro's bioavailability is pretty high (around 90%) but is close to 100% with food so there is no point taking it sublingually. Liver is rarely, if ever, negatively impacted by it. Taking it sublingually may even affect its metabolism, some its metabolites having a significant anti-androgenic and anti-mineralocorticoid effect.
Take it as your doctor prescribes it.
Take it as your doctor prescribes it.