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Has anyone heard of excessive Vitamin D levels or Coq10 messing with the mechanism of estradiol in the body.  I have looked  online and seen a few things on the subject but nothing concrete. When I went to my physical earlier in the year the doctor ran my bloodwork and was like  your vitamin D level  is too low  and recommended to  take a 5,000iu dose dailly,  That to me sounded excessive but oh well I listened and did  what he suggested, I have been taking shots since last January and my progress is there but it has been slow.  I know  it is not a race.  I have recently stopped taking the vitamin d daily and the only vitamin d supplement I am now taking  is in my daily multivitamin.   Since I stopped I don't know  if this  real or not but it just feels different....

I can't answer as to effects with estradiol (I don't take any), 5000 does seem high though. Mine was extremely low and was told to do 1000iu/day. Within months I was normal to slightly above. Now I don't really need any. I take it when I think about it every other day or so just to make sure it doesn't drop. I'll know next visit if I can reduce it further.

  I also take 4900 UI of vitamin D3 a day and I have been satisfied with my HRT progress.

My Vitamin D was low, I took some (1,000) daily, levels went up, felt absolutely no difference in regards to physical effects or how I felt so I dropped it.

Vitamin D is necessary for such things as maintaining and increasing bone density.  So it's important and most people today are deficient. 

I have read several books by doctors that say that everyone should be taking a supplement of 5000 mg vitamin D3 daily to keep the body's level optimal.


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Quote from: Deborah on November 30, 2017, 08:47:12 AM
Vitamin D is necessary for such things as maintaining and increasing bone density.  So it's important and most people today are deficient. 

I have read several books by doctors that say that everyone should be taking a supplement of 5000 mg vitamin D3 daily to keep the body's level optimal.

They are deficient in Calcifediol, 25-hydroxyvitamin D, the prehormone, inactive that is later converted to the more important and critical form,  calcitriol. Notice how those levels, of the active hormone are never measured and it's been brought to my attention by a doctor who's extensively studied the matter that most people are actually not deficient in calcitriol. Food for thought...

Check Vitamin D and Dr. Demers (the myth).

Calcif Tissue Int. 1998 Jan;62(1):26-30.

"Our results confirm the positive effect of 1 year of HRT on serum calcitriol. Vitamin D3 supplementation increased 25OHD concentrations, but did not affect calcitriol concentrations even though the initial levels were low. Interestingly, the combination of HRT and vitamin D3 did not increase serum calcitriol concentrations as much as HRT alone."

HRT alone appears to be effective enough. I don't take Vitamin D and I'm not worried at all. No plans on taking it, ever.

The common incidence of people with poor bone density today is enough evidence for me to take whatever measures available to avoid that.  I take 5000 IU daily and at least so far have not noticed any negative effects.

Because it is fat soluble it stays in your system for about 30 days.  So instead of 5000 IU daily you could take 35000 IU weekly and get the same effect according to the book I read.


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HRT, even at low doses, prevents bone loss and because I intend to take hormones for the remainder of my life, have absolutely no concerns. Vitamin D supplements could actually interfere and make things worse...I encourage you to read more about it, not only the established views...and then you can draw your own conclusions. :)

Why does the Vitamin D Council recommend 5,000 IU/day?
https://www.vitamindcouncil.org/why-does-the-vitamin-d-council-recommend-5000-iuday/

QuoteThe best study that examined the vitamin D levels of people who get plenty of sun exposure was published last year. Researchers discovered that free-living hunter gatherers living around the African equator (where humans evolved) have average vitamin D levels of 46 ng/ml (115 nmol/L).

Most people will not have their blood tested unless their doctor recommends it. So we needed a recommended dose that:

Is easy to obtain at most pharmacies.
Will get at least 97% of people above 30 ng/ml.
Will get most people above 40 ng/ml, and close to around 50 ng/ml.
Will not cause anyone to get toxic levels.

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The question you should ask yourself is: are calcitriol levels high enough in most people? Those levels they measure are of the prehormone, calcifediol.

If most people had levels that were high enough then this wouldn't occur:

Percent of men 65 years of age and over with osteoporosis of the femur neck or lumbar spine: 5.1%
Percent of women 65 years of age and over with osteoporosis of the femur neck or lumbar spine: 24.5%
https://www.cdc.gov/nchs/fastats/osteoporosis.htm

What you have cited here may very well be true.  But as long as a preventative measure is available to optimize health with very low risk of adverse side effects it seems prudent to me to take that measure.  So I take vitamin D3 along with doing exercises that increase bone density.


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If you're worried about low vitamin D levels, go outside more often.  It's safe and quite effective.

 I will do as I've indicated before. I owe my life to what doctors have done for me already. My life has been literally in their hands. I put my faith in their expertise and skills. When they said I needed to take calcium and vitamin D3 to help with a couple deficiencies they saw in my tests, then I take them. It's that simple. No advice I receive here by people who are not doctors, regardless of what they have read, will deter me from following a trained doctor's advice.
  My job was to fix computers for people who could not because they lack my skills. My doctors' jobs are to fix me, because I lack their skill and cannot.

Laurie

Quote from: Laurie on November 30, 2017, 12:19:01 PM
I will do as I've indicated before. I owe my life to what doctors have done for me already. My life has been literally in their hands. I put my faith in their expertise and skills. When they said I needed to take calcium and vitamin D3 to help with a couple deficiencies they saw in my tests, then I take them. It's that simple. No advice I receive here by people who are not doctors, regardless of what they have read, will deter me from following a trained doctor's advice.
  My job was to fix computers for people who could not because they lack my skills. My doctors' jobs are to fix me, because I lack their skill and cannot.

Laurie

In my defense, I am one, but point taken.  ;)

Quote from: rmaddy on November 30, 2017, 10:07:36 AM
If you're worried about low vitamin D levels, go outside more often.  It's safe and quite effective.

If you wear a sunscreen when you go out, you will not be making very much Vitamin D. Also, the same holds true for winter months when we are covered up and the weather is overcast.

A daily vitamin supplement of 400 IU to 1000 IU is plenty enough for most everybody, unless your doctor gives you a specific recommendation for a higher dose.

Quote from: Deborah on November 30, 2017, 10:01:29 AMPercent of men 65 years of age and over with osteoporosis of the femur neck or lumbar spine: 5.1%
Percent of women 65 years of age and over with osteoporosis of the femur neck or lumbar spine: 24.5%
https://www.cdc.gov/nchs/fastats/osteoporosis.htm

Women and men over 65 have low sex hormones. HRT is known to prevent osteoporosis. 

Levels of calcitriol (the active Vitamin D that is most critical to us) are NEVER measured by labs and doctors. Instead the prehormone is. Food for thought...

Quote from: Laurie on November 30, 2017, 12:19:01 PM
I will do as I've indicated before. I owe my life to what doctors have done for me already. My life has been literally in their hands. I put my faith in their expertise and skills. When they said I needed to take calcium and vitamin D3 to help with a couple deficiencies they saw in my tests, then I take them. It's that simple. No advice I receive here by people who are not doctors, regardless of what they have read, will deter me from following a trained doctor's advice.
  My job was to fix computers for people who could not because they lack my skills. My doctors' jobs are to fix me, because I lack their skill and cannot.

Doctors aren't infallible. Being proactive in our treatment is, IMO, certainly not a bad thing. Questioning isn't either, we are all intelligent beings. Discussing with our doctors, challenging them should make them better at their jobs and if anything, they should welcome it. :)

Quote from: KayXo on December 01, 2017, 10:54:27 AM
Women and men over 65 have low sex hormones. HRT is known to prevent osteoporosis. 

That's true.  The other thing with me is that I have a big fear of becoming feeble after taking care of my mother when she was with dementia and so feeble from COPD that she could no longer get out of bed or even turn over by herself.  So I'll do anything to avoid ever getting into that state.

The worst case with vitamin D3 is I'm wasting three dollars a month.



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 :police:

While discussion is encouraged let us be careful that non-medically qualified people do not give medical advice.

Cindy
Forum Admin

I am not a doctor and this is not medical advise.

I take 5000 units or D3 about 6 day a week. I also take K2 form 4 and 7. D3 has can help with calcium uptake among other things and k2 form 4 and 7 places the calcium in the cells. They go hand in hand. My levels are checked every 3 months with my hrt.

I started to supplement D3 when my blood was checked for hrt and my D was low. Most people do not know about it he K2 form 4 and 7 connection. It is like folic acid and b12, always together.

Talk to your doctor and have your blood tested. 25% of your genes need D3.

I tend to be a bit extreme so take what I wrote with a grain of salt.