Susan's Place Transgender Resources

What is the difference between the treatment of Proscar "Finasteride" and spironolactone in from where of feminization
and whichever is better?
How long is the treatment to be used? of "Finasteride" Proscar .
it same spironolactone used 2 years at least? or there is a difference

Both are anti-androgens that block or inhibit the effect of testosterone. They work by different methods.
They do not by themselves 'feminize' as such, they block masculinisation.

I realise that medical help may not be available to you, feminisation is caused by the oestrogen hormone. You need to be very careful in taking it and have blood tests to make sure that you are not harmed.

Can you tell me what country you are in and I may be able to find you some help.

Dear Cindy
you are so kind

" Please read carefully "

I am " Transgender " I am 36 years old I self medication and In my country I can not find support So I look for online support

i started taking the medicine But I take one Tablet spironolactone  in the morning after the food and one Tablet  estradiol  in the evening after the dinner.
" knowing that I do not have  testicles"
- orchiectomy-
I self-castration also  I feel happiness Especially when hormones were introduced When I did a long and painstaking search In this regard and I am like any other Person  needed the support I spent many years of my life looking for treatment even I found information about transgender hormones therapy on YouTube and Google Other than that, I found the treatment I had always dreamed of getting it Finally I go to advances in achieving my dream and my self  - Despite the risks " I will continue "
If you have an assistant give it to me via email All I want is medical follow-up From blood tests and other health care matters if you don't just answer  to my questions only please Because my country does not recognize the rights of transgender people so I can not find help and I am very tired of long and arduous research for knowing what Commensurate with my condition of treatment.
By the way I do contacted many people and sites related to transgender and some specialized treatment centers such as Transcareteam BC and LGBTQ + groups in my country and also close to my country, but I did not get the required help and sometimes I do not get any response.
Plus I do not have much money so I can go to any country's that Progress to me care and support 

Whatever , I live in the Middle East and please email if you want to help me in what I really need

Thanks my love

Quote from: auroratrans on December 30, 2017, 03:14:10 AM
What is the difference between the treatment of Proscar "Finasteride" and spironolactone in from where of feminization
and whichever is better?
How long is the treatment to be used? of "Finasteride" Proscar .
it same spironolactone used 2 years at least? or there is a difference

I was on Spiro for a year and on my most recent followup with my endo the lab work showed my body was having a problem getting my testosterone levels down. My endo then gave me a script for Proscar (Finasteride)to take in addition to the Spiro. She said she had consulted with another endo/group who had more experience in dealing with trans women and the recommendation from them was that I be given the Finasteride.

So taking that, I would say in some cases doctors may believe that neither Spiro or Finasteride is necessarily ''better,'' but that it may be wise to take both at the same time. It varies between each person's unique chemistry to a point where you really should get a professional opinion as to which you should take, because for Spiro vs Fin when it comes to what is best FOR YOU it could be one or the other, neither, or both.

I was on propecia dosages of Finast for hair regrowth before starting HRT, and was told that because the mechanisms are different to keep taking the finast even with spiro.

Quote from: Shadowsister on January 01, 2018, 04:31:34 PM
I was on Spiro for a year and on my most recent followup with my endo the lab work showed my body was having a problem getting my testosterone levels down. My endo then gave me a script for Proscar (Finasteride)to take in addition to the Spiro. She said she had consulted with another endo/group who had more experience in dealing with trans women and the recommendation from them was that I be given the Finasteride.

So taking that, I would say in some cases doctors may believe that neither Spiro or Finasteride is necessarily ''better,'' but that it may be wise to take both at the same time. It varies between each person's unique chemistry to a point where you really should get a professional opinion as to which you should take, because for Spiro vs Fin when it comes to what is best FOR YOU it could be one or the other, neither, or both.

-You are take Proscar (Finasteride) and Spironolactone a both?
-Do proscar (finasteride) cause of depression or not ?
- I heard Proscar is impact the most strong than spironolactone on feminization Do you touched the difference when taken Proscar (Finasteride)?

Big love 💗

Finesteride is not an androgen blocker. Finasteride is a 5alpha reductace inhibitor. 5alpha reductace is an chemical that converts testosterone, androstenedione and DHEA into DiHydroTestosterone. DHT is a much stronger androgen than testosterone, which gives it a higher inhibitory effect on estrogen than testosterone. This makes it useful to take out the body's most potent anti-estrogen. Finesteride can reduce 2/3rds of dht by inhibiting 5alpha reductace only.

Dutasteride is even better, it inhibits both 5alpha and 5beta reductace. 5beta is responsible for 1/3rd of DHT so Dutasteride can reduce DHT to zero in 30 days of use.

Quote from: Bianka Allure on January 08, 2018, 02:13:06 AM
Finesteride is not an androgen blocker. Finasteride is a 5alpha reductace inhibitor. 5alpha reductace is an chemical that converts testosterone, androstenedione and DHEA into DiHydroTestosterone. DHT is a much stronger androgen than testosterone, which gives it a higher inhibitory effect on estrogen than testosterone. This makes it useful to take out the body's most potent anti-estrogen. Finesteride can reduce 2/3rds of dht by inhibiting 5alpha reductace only.

Dutasteride is even better, it inhibits both 5alpha and 5beta reductace. 5beta is responsible for 1/3rd of DHT so Dutasteride can reduce DHT to zero in 30 days of use.

That was important Thanks

Quote from: Bianka Allure on January 08, 2018, 02:13:06 AM5alpha reductace is an chemical that converts testosterone, androstenedione and DHEA into DiHydroTestosterone.

It only converts testosterone to DHT, has no bearing on the other androgens.

QuoteDutasteride is even better, it inhibits both 5alpha and 5beta reductace.

No. Dutasteride inhibits only 5-alpha reductase enzyme but in contrast to finasteride that predominantly inhibits Types 2 and 3 enzyme, dutasteride inhibits all types, 1,2, 3.

Quote from: KayXo on January 08, 2018, 08:45:28 AM
It only converts testosterone to DHT, has no bearing on the other androgens.

No. Dutasteride inhibits only 5-alpha reductase enzyme but in contrast to finasteride that predominantly inhibits Types 2 and 3 enzyme, dutasteride inhibits all types, 1,2, 3.

Androstendione can convert to DHT.

https://www.ncbi.nlm.nih.gov/pubmed/2242346

Androstenedione is an important precursor of dihydrotestosterone in the genital skin of women and is metabolized via 5 alpha-androstanedione.

Abstract

Androgen action is largely determined by the formation of dihydrotestosterone in target tissues. In women, androstenedione is the major precursor of dihydrotestosterone production in female genital skin. The present study was initiated to determine whether androstenedione is converted to dihydrotestosterone primarily via testosterone or 5 alpha-androstane-3,17-dione (5 alpha-androstanedione), and to examine the pathway of androstenedione metabolism in genital skin. Genital skin was obtained from 9 normal premenopausal women and 2 normal men. Each tissue was incubated with [3H]androstenedione in RPMI-1640 medium for 1 h at 37 degrees C in 95% O2/5% CO2. The metabolites were separated and purified by paper partition and thin-layer chromatography. The conversions of androstenedione to 5 alpha-androstanedione and to androsterone were similar (10.45 +/- 1.46 and 11.04 +/- 2.04%/200 mg tissue), and were approx. 12, 8 and 23 times higher than the conversion of androstenedione to testosterone, dihydrotestosterone and 5 alpha-androstane-3 alpha,17 beta-diol, respectively. The male samples showed a similar pattern of metabolism. These data indicate that 5 alpha-androstanedione is the most important intermediate in the conversion of androstenedione to dihydrotestosterone. The data also confirm the importance of 5 alpha-reductase activity over that of 17 beta-hydroxysteroid oxidoreductase activity in the expression of androgen action in women.



What I like about Dutasteride is it is has roughly double the half life of Finesteride, around 3 weeks for finesteride versus 6 1/2 weeks for dutasteride once it has built up to it's serum concentration. It stays in the system very long and only needs a very low dose to build up. In 30 days it reduces DHT to zero. With finesteride used at the maximum dose one third of DHT will remain and DHT is a very potent estrogen blocker. DHT also converts to androstenediol which is a stronger androgen than DHT. 

Quote from: auroratrans on January 02, 2018, 01:04:42 AM
-You are take Proscar (Finasteride) and Spironolactone a both?
-Do proscar (finasteride) cause of depression or not ?
- I heard Proscar is impact the most strong than spironolactone on feminization Do you touched the difference when taken Proscar (Finasteride)?

Big love 💗

I am sorry it took me so long to respond to you. I missed your message.

-My doctor gave me instructions to take both Proscar and Spiro

-I am deeply depressed and am not sure if it's the Proscar. I was depressed before taking it, and lately the depression has been getting worse, but bear in mind I live in incredibly depressing household with very passive-aggressive, fake people who emotionally hurt me. It gets worse around the Holidays, which is around the time I started taking Proscar.

-I have not been on Proscar long enough to notice any more powerful feminization effects. I am not sure whether it is stronger than Spiro, or by what metric one would use to define that strength.


Hope that helps a bit, and again I am sorry it took me so long to respond to you.

If you are having depression on Proscar, discuss this with your doctor as soon as possible. Depression is a very rare but serious side effect of this medication so the cause of your depression should be evaluated and if it's the Proscar, it should be discontinued.

Quote from: Dena on January 08, 2018, 11:04:35 PM
If you are having depression on Proscar, discuss this with your doctor as soon as possible. Depression is a very rare but serious side effect of this medication so the cause of your depression should be evaluated and if it's the Proscar, it should be discontinued.

The people injured depressed  before maybe Be vulnerable to depression again Due to the use  proscar?

Quote from: auroratrans on December 30, 2017, 12:37:03 PM

" knowing that I do not have  testicles"
- orchiectomy-
I self-castration ...

If you no longer have your testicles, then you are NOT producing very much Testosterone at all. You most likely do not need to take any Testosterone blocker. Just keep taking the Estradiol.

Quote from: auroratrans on January 09, 2018, 02:28:09 AM
The people injured depressed  before maybe Be vulnerable to depression again Due to the use  proscar?

It is possible but I know that depression while on Finesteride can be deadly. We have one member who realized the drug was the source of the problem and quit. It took several weeks for the depression to clear. There was another member who was on the drug for around a year and only joined the site about a month before committing suicide. We attempted to warn them of the drug's danger but they were unable to connect the drug to the serious depression they were feeling. They instead blamed the depression on the fact that they were transgender.