Community Conversation => Transitioning => Hormone replacement therapy => Topic started by: Amy Chislett on August 18, 2018, 04:33:42 PM Return to Full Version
Title: Finasteride
Post by: Amy Chislett on August 18, 2018, 04:33:42 PM
Post by: Amy Chislett on August 18, 2018, 04:33:42 PM
Spiro will have to wait for another poll. Fin only answers here, please.
Title: Re: Finasteride
Post by: Shellie Hart on August 18, 2018, 09:10:22 PM
Post by: Shellie Hart on August 18, 2018, 09:10:22 PM
Quote from: Amy Chislett on August 18, 2018, 04:33:42 PMBeen on finasteride for 10 years for hair loss.
Spiro will have to wait for another poll. Fin only answers here, please.
Title: Re: Finasteride
Post by: Dani on August 18, 2018, 09:16:23 PM
Post by: Dani on August 18, 2018, 09:16:23 PM
Amy,
I cannot find any reports of any need for caution with potassium intake while taking Finasteride.
Can you tell us where your concern came from?
I cannot find any reports of any need for caution with potassium intake while taking Finasteride.
Can you tell us where your concern came from?
Title: Re: Finasteride
Post by: Amy Chislett on August 28, 2018, 02:05:58 PM
Post by: Amy Chislett on August 28, 2018, 02:05:58 PM
Merck Manuel says drugs like spiro can interfere with K uptake.
Title: Re: Finasteride
Post by: TonyaW on August 28, 2018, 03:35:24 PM
Post by: TonyaW on August 28, 2018, 03:35:24 PM
Different class of drugs, no issues with potassium from finasteride.
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Sent from my SM-G930T using Tapatalk
Title: Re: Finasteride
Post by: josie76 on August 28, 2018, 07:07:17 PM
Post by: josie76 on August 28, 2018, 07:07:17 PM
Finasteride blocks two versions of the enzyme alpha5-reductase. This enzyme converts testosterone to dihydrotestosterone. The drug does not greatly affect other systems outside of those needing this particular enzyme.
Spironolactone on the other hand does directly interface with cell receptors. The androgen receptor is a secondary point for it. It primarily latches to mineralcorticoid and glucocorticoid receptors. It's the activity in those systems that causes increased water egress but does not trigger an increase in potassium flushing. This is why potassium levels can become dangerously high if sodium gets flushed out too much.
Spironolactone on the other hand does directly interface with cell receptors. The androgen receptor is a secondary point for it. It primarily latches to mineralcorticoid and glucocorticoid receptors. It's the activity in those systems that causes increased water egress but does not trigger an increase in potassium flushing. This is why potassium levels can become dangerously high if sodium gets flushed out too much.
Title: Re: Finasteride
Post by: Dani on August 28, 2018, 08:09:52 PM
Post by: Dani on August 28, 2018, 08:09:52 PM
Quote from: Amy Chislett on August 28, 2018, 02:05:58 PM
Merck Manuel says drugs like spiro can interfere with K uptake.
This is very important with Spironolactone because it is also a potassium sparing diuretic used to treat hypertension. Too much potassium can cause problems.
Title: Re: Finasteride
Post by: Amy Chislett on August 30, 2018, 05:37:54 PM
Post by: Amy Chislett on August 30, 2018, 05:37:54 PM
I guess it did not cause my A Fib. Never can be too sure. Wonder if respondents had marginal kidneys to begin with, tho.