Susan's Place Transgender Resources

I finally found documentation that supported my thoughts on the benefits of taking Progesterone along with Estradiol and Spironolactone.  I contacted my endocrinologist to present my case.  He has known that I've been interested in progesterone.  After he read the newest article in The Journal of Clinical Endocrinology & Metabolism, he agreed to give me a starting dosage for three months and see how I do.  It's in the mail, probably here in a few days.

The article I refer to is detailed in the thread Progesterone Is Important for Transgender Women's Therapy (https://www.susans.org/forums/index.php/topic,245188.msg2234731.html#msg2234731)

I started E and spiro nearly 20 months ago.  My levels were in February at, Estradiol: 122 pg/mL
Testosterone: 21 ng/dL.  Because of those good numbers I requested to reduce my spiro dosage.

I'm anticipating some changes when I start.  I understand that breast growth can include ductal development after taking progesterone and bone density is purported to increase.
I plan to request a bone density test to create a baseline to measure if it is true, though of course if it isn't evident in my results, it could be different than others.
I don't buy into some people's thoughts that mood can be effected dramatically.  I will be taking an bio-identical micronized progesterone, which has evidenced not to have that side effect.

I must stress that there isn't enough information gathered to have a clear picture.
So I will update this thread as I start this stretch of transition road.  Giving highlights, good and bad, dramatic or insignificant.

Stay tuned.  Hopefully this will help give an idea of what may occur.

Hugs and smiles, Jessica 🌸🌸🌸

Quote from: Jessica on March 10, 2019, 12:30:18 AM
I finally found documentation that supported my thoughts on the benefits of taking Progesterone along with Estradiol and Spironolactone.  I contacted my endocrinologist to present my case.  He has known that I've been interested in progesterone.  After he read the newest article in The Journal of Clinical Endocrinology & Metabolism, he agreed to give me a starting dosage for three months and see how I do.  It's in the mail, probably here in a few days.

The article I refer to is detailed in the thread Progesterone Is Important for Transgender Women's Therapy (https://www.susans.org/forums/index.php/topic,245188.msg2234731.html#msg2234731)

I started E and spiro nearly 20 months ago.  My levels were in February at, Estradiol: 122 pg/mL
Testosterone: 21 ng/dL.  Because of those good numbers I requested to reduce my spiro dosage.

I'm anticipating some changes when I start.  I understand that breast growth can include ductal development after taking progesterone and bone density is purported to increase.
I plan to request a bone density test to create a baseline to measure if it is true, though of course if it isn't evident in my results, it could be different than others.
I don't buy into some people's thoughts that mood can be effected dramatically.  I will be taking an bio-identical micronized progesterone, which has evidenced not to have that side effect.

I must stress that there isn't enough information gathered to have a clear picture.
So I will update this thread as I start this stretch of transition road.  Giving highlights, good and bad, dramatic or insignificant.

Stay tuned.  Hopefully this will help give an idea of what may occur.

Hugs and smiles, Jessica [emoji254][emoji254][emoji254]

I bet you develop c-cups quicker than one can say pre-menstral tension !

Kindest regards, Kirsten.

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In breasts, estrogen stimulates the growth of the ductal system, while lobular development depends on progesterone, making breasts fuller, rounder and able to secrete more milk.

At the moment, experts in transgender treatment admit (in a recent article published) that more research is needed and we don't know whether progesterone helps with breast development/feminization, the evidence is too sparse. Anecdotally, some girls report positive effects.

@KayXo

Quote from: KayXo on March 10, 2019, 09:07:58 AM
In breasts, estrogen stimulates the growth of the ductal system, while lobular development depends on progesterone, making breasts fuller, rounder and able to secrete more milk.

At the moment, experts in transgender treatment admit (in a recent article published) that more research is needed and we don't know whether progesterone helps with breast development/feminization, the evidence is too sparse. Anecdotally, some girls report positive effects.

Thank you Kay for your absolutely correct information.  I'm hoping now that more transgender women will be prescribed progesterone so research data can be compiled.

One other thing I'm anticipating is better sleep.  Even though I average between 6-7 hours every night, I feel it could be more. 
Progesterone is recommended to be taken at night due to the effect of making you feel sleepy.

Quote from: Jessica on March 10, 2019, 12:38:48 PM
One other thing I'm anticipating is better sleep.  Even though I average between 6-7 hours every night, I feel it could be more. 
Progesterone is recommended to be taken at night due to the effect of making you feel sleepy.

This would be a big benefit for me, because my average night sleep is 5 to 6 hours!  This makes me to take a nap in the early afternoon.  I get my 7 to 8 hours of total sleep in most 24 hour periods, but it would be nice not to waste part of the day with sleeping.

I'm averaging about the same according to my Fitbit, but I hit 7+ hours seven  times in the last 3 months taking the progesterone where it was just once in three months prior to starting.  I'd been taking it at about 5pm with my second spiro dose but plan to switch that to bedtime when I get my refill tomorrow

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I was hoping that my sleep pattern would improve now that I am liberated from spiro, but it has not changed at all.
Increased estrogen seems not have any effect on sleeping either (I monitor my sleep with my Samsung smart watch, which is, according to Consumer Report, pretty accurate in monitoring bodily functions).

If progesterone could zonk me out for an additional 2 hours per night, just that alone would be worth the while for taking this stuff! 

I can also report the good benefit of sleeping more while on progesterone oral micronized. When I first started to take it I would be able to sleep longer at night, about 2 hours more, and also if I ended up taking it during the day I would end up taking a nap! And Naps were almost never something I ever took due to my anxiety issues; always too tight strung. Progesterone helped alot for sleep.

However, after I started Dutasteride the sleepy effect got greatly reduced. I think it is due to the blockage of the 5areductace enzyme which is also able to take in progesterone and convert it to allopregnanolone and I believe it was the allopregnanolone which caused me to get sleepy and also hungry at least from what I recall. Hungry was also good because at times I just don't eat as much as I could. Now I almost feel immune to the sleepy effect of progesterone.... almost.

Also, thank you for the article. I will print this and show it to me doc next time I am up for a visit; 2 months. I want to be switched from oral progesterone to inj progesterone in oil. Reason being that oral progesterone does a double pass through the liver because it uses the portal vein from the intestine first, which goes straight to the liver, before going into main circulation. So the med does a double pass which I feel is double the work. Short term I think it is ok, but long term for the rest of my life it isn't. Also my doc has me on <dosage removed> daily. That's <dosage removed> weekly which I feel is too much. Even if my body doesn't absorb it all I am still putting <dosage removed> in my body per week. If it was inj progesterone in oil it would only be a small tiny fraction of that because of bio ability of injectables. I am seriously concerned. My doc says there is no data suggesting damage or issues with oral micronized P, but how long were the studies? Were they 30+ 50+ years? Long Term? I started HRT when i was 21 and I am going to be 34 in april. I still have a way to go. At least 30 more years i'd hope! I'd rather just be on inj pio with a much smaller dosage instead of this huge amount that is being placed inside my body.

So thank you for the article.

Also, I did notice a lot of rounding and filling of my breasts. They just looked so much fuller and I had a history with tubular breasts for the longest time. And I had started with inj EV I believe just a few months after starting hrt at 21 and the tubular breasts had been an issue since. Progesterone seemed to greatly help with the rounding. I also have the goal of being able to lactate at some point I just need things to align properly and if it helps with the lobules to secrete more milk then that is great news.



<dosages removed by moderator>

Quote from: Asakawa on March 10, 2019, 05:33:42 PM
I can also report the good benefit of sleeping more while on progesterone oral micronized. When I first started to take it I would be able to sleep longer at night, about 2 hours more, and also if I ended up taking it during the day I would end up taking a nap! And Naps were almost never something I ever took due to my anxiety issues; always too tight strung. Progesterone helped alot for sleep.

However, after I started Dutasteride the sleepy effect got greatly reduced. I think it is due to the blockage of the 5areductace enzyme which is also able to take in progesterone and convert it to allopregnanolone and I believe it was the allopregnanolone which caused me to get sleepy and also hungry at least from what I recall. Hungry was also good because at times I just don't eat as much as I could. Now I almost feel immune to the sleepy effect of progesterone.... almost.

Also, thank you for the article. I will print this and show it to me doc next time I am up for a visit; 2 months. I want to be switched from oral progesterone to inj progesterone in oil. Reason being that oral progesterone does a double pass through the liver because it uses the portal vein from the intestine first, which goes straight to the liver, before going into main circulation. So the med does a double pass which I feel is double the work. Short term I think it is ok, but long term for the rest of my life it isn't. Also my doc has me on <dosage removed> daily. That's <dosage removed> weekly which I feel is too much. Even if my body doesn't absorb it all I am still putting <dosage removed> in my body per week. If it was inj progesterone in oil it would only be a small tiny fraction of that because of bio ability of injectables. I am seriously concerned. My doc says there is no data suggesting damage or issues with oral micronized P, but how long were the studies? Were they 30+ 50+ years? Long Term? I started HRT when i was 21 and I am going to be 34 in april. I still have a way to go. At least 30 more years i'd hope! I'd rather just be on inj pio with a much smaller dosage instead of this huge amount that is being placed inside my body.

So thank you for the article.

Also, I did notice a lot of rounding and filling of my breasts. They just looked so much fuller and I had a history with tubular breasts for the longest time. And I had started with inj EV I believe just a few months after starting hrt at 21 and the tubular breasts had been an issue since. Progesterone seemed to greatly help with the rounding. I also have the goal of being able to lactate at some point I just need things to align properly and if it helps with the lobules to secrete more milk then that is great news.



<dosages removed by moderator>

Thank you so much for relating your experience.  Very interesting real life information.

You may have noticed that the dosages you provided were removed (they aren't allowed on the site), but the text was important to preserve.
Thank you for sharing.

Hi all, I took my first dose of progesterone last night.....
I slept for 9 hours, that's an increase of 2-3 more than my average.  I have to admit though that the previous night I had only 4 because of a bit of anxiety due to insecurities from issues with my wife. (It's better now)
During last night I woke just once to pee and found my sleep shirt soaked with sweat, that is unusual considering it was a cool night.  After putting on a dry one, I found myself now cold.....interesting.

I also want to put on record my measurements at this point so I can validate any changes in breast size and fat redistribution.

For individual breast growth I measure from the spot on the clavicle straight up from the nipple to the crease below.

Rhonda is 11 1/2"
Lucy is 11 1/4"
They both were 8 3/4" when I started HRT 1 1/2+ years ago.
Both are doing the Snoopy nose at the moment, and from experience, they should round out in about a week.  We will see if the progesterone will effect that.

My bust is 41" (an increase of 4")
Band is 36" (decreased by 2")
Waist is 35" (decreased by 3")
Hips are 42" (increase of 4")
Thighs are 23 1/2" (increase of 3 1/2")

Hugs and smiles, Jessica

Quote from: Jessica on March 12, 2019, 12:10:53 PM
Hi all, I took my first dose of progesterone last night.....
I slept for 9 hours, that's an increase of 2-3 more than my average.  I have to admit though that the previous night I had only 4 because of a bit of anxiety due to insecurities from issues with my wife. (It's better now)
During last night I woke just once to pee and found my sleep shirt soaked with sweat, that is unusual considering it was a cool night.  After putting on a dry one, I found myself now cold.....interesting.

Those night sweats could be due to progesterone's 1) anti-estrogenic effect 2) body temperature increase. I got that as well. ;)

Thanks Jess.  It will be interesting to see you chronicle this in detail.  I too am on P, but I haven't been keeping track of things at all really.

Good evening Ladies,

Today I recieved a prescription for Besins Prometrium from my Endo Doctor.( smiling big time!)

The advice I was given was that it may or may not be beneficial. It is considered amongst the safest progesterone medications.

There was the suggestion that future extra breast growth could be the result of water retention/ bloating or maybe development of breast tissue structures.

  Also the effect on mood may prove to be positive or negative. Some patients have reported feeling off or "flat" some always feel better with it.

My doctor suggested non-cycling rgimen to maximise mood and minimise side effects- I will follow this advice for 2 months.

At 2 months it will be reassesed and continued?

In the morning I will measure vital dimensions to get a baseline for future growth.

Yours with anticipation, Kirsten xx.

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  Kirsten, Additional breast growth would be nice, yes. But at my age 66 I will be thankful for any and all of the other benefits micronized progesterone might possibly bestow on me. They are far more important to me and a good arguement to convince one's doctor.

Laurie

Quote from: Laurie on March 30, 2019, 06:48:11 PM
  Kirsten, Additional breast growth would be nice, yes. But at my age 66 I will be thankful for any and all of the other benefits micronized progesterone might possibly bestow on me. They are far more important to me and a good arguement to convince one's doctor.

Laurie

I am interested in your take on progesterone Laurie. What would you like to gain from the medication ? Do you find it better for mood, feminisation, curvaceous figure ?

Yours with interest, Kirsten.

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Hi Kirsten,

  First off let me say that my reference comes from the Endocrine Society magazine article Progesterone Is 1)Important for Transgender Women's Therapy—Applying Evidence for the Benefits of Progesterone in Ciswomen
https://academic.oup.com/jcem/article/104/4/1181/5270376 (https://academic.oup.com/jcem/article/104/4/1181/5270376)


  I will let you read the information yourself. But the ones that interest are the possible cardiovascular possibilities, the possible cancer  risk lessening, and the bone mass help it may give. Since I have experienced cancer 3 times now and am supposed to be dead twice already, I will take any help I can get.  I have emphysema and atherosclerosis so I could use the possible cardio-vascular help. I also have been diagnosed wit osteopenia which is the start of osteoporosis,  so if it helps bone mass density I could use that also.  I hope that answers your question.

Hugs,
  Laurie

Quote from: Laurie on March 30, 2019, 11:00:29 PM
Hi Kirsten,

  First off let me say that my reference comes from the Endocrine Society magazine article Progesterone Is 1)Important for Transgender Women's Therapy—Applying Evidence for the Benefits of Progesterone in Ciswomen
https://academic.oup.com/jcem/article/104/4/1181/5270376 (https://academic.oup.com/jcem/article/104/4/1181/5270376)

  I will let you read the information yourself. But the ones that interest are the possible cardiovascular possibilities, the possible cancer  risk lessening, and the bone mass help it may give. Since I have experienced cancer 3 times now and am supposed to be dead twice already, I will take any help I can get.  I have emphysema and atherosclerosis so I could use the possible cardio-vascular help. It also have been diagnosed wit osteopenia which is the start of osteoporosis  so if it helps bone mass density I could use that also.  I hope that answers your question.

Hugs,
  Laurie

It does thank you Laurie. Also I believe if a pre- menopause estrogen level is maintained then bone density is maintained.

Yours Kirsten


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I have been taking Micronized Progesterone for about 10 years (when I can get it)
I have tried the 10 day cycle thing and just taking it every day.  At time it has made me quite sleepy sometimes not.
Gone off all hrt several times due to funds, and since the Progesterone...have lactated every single time.
Last time I experienced a wayward duct that got clogged with thick milk and gave me what seems to be an upside down semi colon protruberance/pimple thing on one side.
My breasts are seemingly never going to really fill out, so I don't reflect the fuller development idea.
I DO feel more "normal" for lack of a better description when I take the Pro at least 10 days a month.
I sure hope your results are all you hope for.
Barri

This was all interesting reading.  It seems that Progesterone may not necessarily be of help, but it may help with providing results of more of the desired body changes and better sleep, bones, and cardiac condition.  However, it may work against estrogen, which could mean that progesterone suppresses some of the desired body changes. 

This makes me wonder if the dose of estrogen that your doctor has you on matters when you also use Progesterone, and if the dosage of Progesterone should be somehow proportional to the dose of Estrogen used.  This I leave up to the physicians who should know what to do when prescribing Mtf HRT.

Also, it seems that micronized Progesterone is the type to use.

It is unclear to me if Progesterone should be used in monthly cycles or throughout the month.

It is clear to me that talking about using Progesterone when meeting with the doctor who manages your mtf HRT is worthwhile to do at least.

Did I miss any important considerations for using or not using Progesterone? 

Chrissy

@ChrissyRyan

Quote from: ChrissyRyan on April 06, 2019, 09:33:45 PM
This was all interesting reading.  It seems that Progesterone may not necessarily be of help, but it may help with providing results of more of the desired body changes and better sleep, bones, and cardiac condition.  However, it may work against estrogen, which could mean that progesterone suppresses some of the desired body changes. 

This makes me wonder if the dose of estrogen that your doctor has you on matters when you also use Progesterone, and if the dosage of Progesterone should be somehow proportional to the dose of Estrogen used.  This I leave up to the physicians who should know what to do when prescribing Mtf HRT.

Also, it seems that micronized Progesterone is the type to use.

It is unclear to me if Progesterone should be used in monthly cycles or throughout the month.

It is clear to me that talking about using Progesterone when meeting with the doctor who manages your mtf HRT is worthwhile to do at least.

Did I miss any important considerations for using or not using Progesterone? 

Chrissy

Were you able to visit my Progesterone Is Important for Transgender Women's Therapy (https://www.susans.org/forums/index.php/topic,245188.0.html) thread?  That gives a new vision in the use of Progesterone.

I have to say that you have a very good thought about the balance between Estradiol and Progesterone, I have had the same idea.

Quote from: Jessica on April 06, 2019, 09:55:49 PM
@ChrissyRyan

Were you able to visit my Progesterone Is Important for Transgender Women's Therapy (https://www.susans.org/forums/index.php/topic,245188.0.html) thread?  That gives a new vision in the use of Progesterone.

I have to say that you have a very good thought about the balance between Estradiol and Progesterone, I have had the same idea.

@Jessica


Jessica,

I will read through your thread you mentioned, thank you for pointing it out.  I have been busy for a number of weeks now and have not been that thorough with my reading here for awhile, with a lot of of me quickly popping in and out online.

You have a nice figure. Thanks for helping out here on Susan's.  It is appreciated, as is all the work the rest of the staff does.   :)

Hugs,

Chrissy

So after about 5 weeks of adding Progesterone I've gained 1/2" to my bust!

Hugs and smiles 🌸🌸🌸

Quote from: Jessica on April 17, 2019, 01:42:15 PM
So after about 5 weeks of adding Progesterone I've gained 1/2" to my bust!

Hugs and smiles 🌸🌸🌸

I don't rember, were you cycling Progesterone, or taking it daily?  I had been cycling it 10 days on January through March, then April 1st, I switched to daily (well technically, April 1-10 was the days on, but April 10th, my Dr. switched me to daily, and my prescription was ready April 11th).

I too have noticed an increase in my bust, but I don't know exactly how much, as some days it was 1/2inch ot 3/4inches, other days 1/2inch or less.

@Myranda

Quote from: Myranda on April 17, 2019, 03:57:45 PM
I don't rember, were you cycling Progesterone, or taking it daily?  I had been cycling it 10 days on January through March, then April 1st, I switched to daily (well technically, April 1-10 was the days on, but April 10th, my Dr. switched me to daily, and my prescription was ready April 11th).

I too have noticed an increase in my bust, but I don't know exactly how much, as some days it was 1/2inch ot 3/4inches, other days 1/2inch or less.

Hi Myranda, I do not cycle and take it daily before I go to bed.
I do see fluctuations in the apparent size of my areolae, but I haven't seen that happening with my breast size.

Well considering it has been 17 days now that I have been taking it every day, I can't that the daily regimen is behind the flucations, it was probably  the cycling, which I think would be normal to some extent for Women.

Quote from: Jessica on April 17, 2019, 01:42:15 PM
So after about 5 weeks of adding Progesterone I've gained 1/2" to my bust!

Hugs and smiles

That is impressive.  Congratulations Jessica. 

Chrissy

@Myranda

Quote from: Myranda on April 17, 2019, 04:54:47 PM
Well considering it has been 17 days now that I have been taking it every day, I can't that the daily regimen is behind the flucations, it was probably  the cycling, which I think would be normal to some extent for Women.

Hi Myranda, daily doses were determined by my endocrinologist after I supplied him with a new paper from the Endocrinologist society.  Here is a link to my thread that includes this.

Progesterone Is Important for Transgender Women's Therapy (https://www.susans.org/forums/index.php/topic,245188.msg2234731.html#msg2234731)

And here is the paragraph in it about that.

QuoteThat cyclic P4 is necessary for ciswomen's fertility is well recognized (9); it is less well appreciated that within regular, normal-length cycles, P4 levels and ovulation are quite variable between cycles within-woman and between women (10). This variability provided the opportunity to "see" the adverse health effects (e.g., on changes in bone density) of subclinical ovulatory disturbances (anovulation or short/insufficient luteal phases within regular cycles) (10, 11). Perhaps because of cumulative and daily life stressors, approximately one-third of regular, normal-length menstrual cycles in ciswomen, ages 20 to 49, are without sufficient P4 (12). Normal ovulation and regular menstruation during the premenopausal years in ciswomen are necessary to prevent bone loss, based on a meta-analysis of prospective observational studies (10) and are associated with a decreased incidence of heart disease within 10 years of menopause onset (13) and with potential breast cancer prevention (14, 15). Progesterone "area under the curve" levels across the menstrual cycle exceed those of integrated menstrual cycle E2 levels in ciswomen's ovulatory cycles because progesterone is produced in nanomoles per liter and E2 in picomoles per liter quantities (15). For metabolic and antiandrogen effects [to suppress LH and gonadal testosterone (T) and inhibit the conversion of T to dihydro-T (DHT)], I suggest that transgender women's progesterone be given daily rather than cyclically, at least until orchiectomy and always at bedtime, because of its sleep-enhancing effects (as subsequently discussed).

Hugs, Jess

@ChrissyRyan

Quote from: ChrissyRyan on April 17, 2019, 05:12:30 PM

That is impressive.  Congratulations Jessica. 

Chrissy

Thanks Chrissy!  I'm pretty happy about them.

Quote from: Jessica on April 17, 2019, 05:19:09 PM
@Myranda

Hi Myranda, daily doses were determined by my endocrinologist after I supplied him with a new paper from the Endocrinologist society.  Here is a link to my thread that includes this.

Progesterone Is Important for Transgender Women's Therapy (https://www.susans.org/forums/index.php/topic,245188.msg2234731.html#msg2234731)

And here is the paragraph in it about that.

Hugs, Jess

Yaah, after I showed my doctor that paper they switched me to daily progesterone as well.

Jess, I feel like I grew a 1/2 inch last night.  Yesterday I measured and I was 41 under, 42.5 over, and today while I was brushing my teeth, they looked noticably large and more defined, so I measured, and I was 41 under and 43 over, with very distinct shape and contour

Quote from: Jessica on March 10, 2019, 12:38:48 PM
One other thing I'm anticipating is better sleep.  Even though I average between 6-7 hours every night, I feel it could be more. 
Progesterone is recommended to be taken at night due to the effect of making you feel sleepy.

Jessica,

Have you found that you have been getting better sleep too now with the Progesterone?

Chrissy

Quote from: ChrissyRyan on April 20, 2019, 11:56:04 AM

Jessica,

Have you found that you have been getting better sleep too now with the Progesterone?

Chrissy

When I mentioned the better sleep to my endo, he barked at me what a poor way to try to get better sleep!

Linde,

Well you did not take Progesterone solely for better sleep, but better sleep was a by-product, and bonus.  But this makes me wonder if guys who are not transitioning would get better sleep with by taking P.  Perhaps they would not get breast development unless they also took Estrogen. But that is just a random thought.  I doubt this is a prescribed use of Progesterone for men unless there were use-affirming bona fide medical studies on this use of progesterone!

Jessica said she had good sleep before taking Progesterone.  I am wondering if it improved any, that may not be possible with existing good sleep.

Were you getting your better sleep from a pill or a cream, I think you said you used a cream, but it resulted in you having little or no noticeable breast changes.

Chrissy

Quote from: Dietlind on April 20, 2019, 11:58:58 AM
When I mentioned the better sleep to my endo, he barked at me what a poor way to try to get better sleep!

This guy sounds like a real piece of work.

Quote from: ChrissyRyan on April 20, 2019, 12:26:32 PM
Linde,

Well you did not take Progesterone solely for better sleep, but better sleep was a by-product, and bonus.  But this makes me wonder if guys who are not transitioning would get better sleep with by taking P.  Perhaps they would not get breast development unless they also took Estrogen. But that is just a random thought.  I doubt this is a prescribed use of Progesterone for men unless there were use-affirming bona fide medical studies on this use of progesterone!

Jessica said she had good sleep before taking Progesterone.  I am wondering if it improved any, that may not be possible with existing good sleep.

Were you getting your better sleep from a pill or a cream, I think you said you used a cream, but it resulted in you having little or no noticeable breast changes.

Chrissy

Any physician can prescribe any medication for it's side effect.  Sprio was not meant to be a T blocker, Finasteride was not meat to grow hair. etc.
The sleep benefits was a last ditch effort I tried to make to get him to prescribe the P pill for me.  Did not work either.
I am in the 4th week of using OTC micronized progesterone cream, applied to my breasts.  I will likely stop with this, once this dose is gone.
If there i any effect to be seen, it is very minimal at best, and i do't now if it is because of the increased E after the orchi, or because of P, or because of both of them!  anyway the outcome is in no relation to the cost of $20 per month.

I do not feel any other influence either, no better sleep, or anything one could think of.  To correct this, one outcome is nice and soft skin on the boobs, but I can have that for a lot less money!

To summarize this experiment, I wasted about $100 for nothing, it would have been a better investment, to buy a few bottles of nice wine for it!

I cannot recommend to spend money for any OTC  topical progesterone cream!

Quote from: Myranda on April 20, 2019, 02:04:21 PM
This guy sounds like a real piece of work.

He is absolutely full of himself.  It came down to an act I normally don't like to do, to pull my PhD.  Now when I check in, I say Dr. XX to see Dr. YYY.  That seems to work a little!

Update!  Still not sure if the progesterone has been the cause for any changes, or if it is how it would have gone anyway.
But in the last two weeks I've experienced weekly the breast growth spurts I experienced every three months before starting Progesterone. My areolae during the same time increased from 2" to 2 1/4" and the nipples are a vivid pink!
I also have noticed my breasts getting more in the way and I can't cross my arms across my body the same as I used to.

Hugs and smiles from a California girl

I am very much interested in a progesterone addition to my HRT.  Thank you for sharing your experience and the link to some good resources.


Bea

Quote from: Jessica on April 30, 2019, 03:18:38 PM
Update!  Still not sure if the progesterone has been the cause for any changes, or if it is how it would have gone anyway.
But in the last two weeks I've experienced weekly the breast growth spurts I experienced every three months before starting Progesterone. My areolae during the same time increased from 2" to 2 1/4" and the nipples are a vivid pink!
I also have noticed my breasts getting more in the way and I can't cross my arms across my body the same as I used to.

Hugs and smiles from a California girl

@Jessica
Dear Jess:
I consider it good news as you described your breast growth and having to experience some difficulty with your breasts getting in the way.

I have noticed the very same things with my C-cup breasts.  When I am working on detailed paperwork I tend to lean over and down toward my desk and my breasts get in the way so I make sure that they are on top and over the edge of the desk  ....   
....also when eating or drinking I experience my food dribblings ending up on the front of my tops and/or dress.... my breasts make a perfect shelf for catching those kinds of things.

Happy troubles for sure!!!  ;)
Thank you for sharing,
Hugs,
Danielle

Quote from: Alaskan Danielle on April 30, 2019, 03:28:42 PM
@Jessica
Dear Jess:
I consider it good news as you described your breast growth and having to experience some difficulty with your breasts getting in the way.

I have noticed the very same things with my C-cup breasts.  When I am working on detailed paperwork I tend to lean over and down toward my desk and my breasts get in the way so I make sure that they are on top and over the edge of the desk  ....   
....also when eating or drinking I experience my food dribblings ending up on the front of my tops and/or dress.... my breasts make a perfect shelf for catching those kinds of things.

Happy troubles for sure!!!  ;)
Thank you for sharing,
Hugs,
Danielle

I must ask Danielle, at the risk of being a sticky beak, was progesterone part of your HRT to gain such substantial growth ?

Kirsten.

Sent from my SM-G930F using Tapatalk

Again, I cannot really tell if it is the change to dialy progesterone, or just the effects of regular E and having been on Progesterone again since restarting everything back in January, when I was on regeimen of E and Cycling P, but at the start of April I switched to Daily P, and since then, my breasts have been quite tender and at times  quite full for their size.  I have also noticed a distinct change in the way my nipples feel, they are much more firm, even when they are not "cold" and pointy.  and I must say I really like the way they feel to the touch now compared to before.  I wil lre measure everything again on the 10th.

Quote from: Kirsteneklund7 on April 30, 2019, 03:35:02 PM
I must ask Danielle, at the risk of being a sticky beak, was progesterone part of your HRT to gain such substantial growth ?

Kirsten.

Sent from my SM-G930F using Tapatalk

@Kirsteneklund7
Dear Kirsten:
No, just "standard" HRT .... spiro and estrogen  ... started in March 2015
I know that Progesterone is a big contributor to breast development but I did not need or want it. 
My genetic makeup seemed to work well with the initial HRT.  In just a year of HRT I had almost a B-cup, at 2 years almost a C cup and at 3 years a full C-cup and thankfully I am at the 4+ year point of HRT and breast growth stopped... 
...or hopefully stopped! ???  ::)  ;)
I am more than happy with C-Cup and no larger... I did not want to inhibit my very active lifestyle with big bouncing breasts.

Hugs,
Danielle

Quote from: Myranda on April 30, 2019, 04:19:35 PM
Again, I cannot really tell if it is the change to dialy progesterone, or just the effects of regular E and having been on Progesterone again since restarting everything back in January, when I was on regeimen of E and Cycling P, but at the start of April I switched to Daily P, and since then, my breasts have been quite tender and at times  quite full for their size.  I have also noticed a distinct change in the way my nipples feel, they are much more firm, even when they are not "cold" and pointy.  and I must say I really like the way they feel to the touch now compared to before.  I wil lre measure everything again on the 10th.

I have the same feeling in my breasts and nipples from just being on estrogen.  I don't know if this is a good measurement criteria to see if P helps.
To find this out, we would need some women just taking P, some other just taking E, and another group taking E and P , and a control group not taking either.

Who is willing to start a study?

Quote from: Alaskan Danielle on April 30, 2019, 04:35:42 PM
@Kirsteneklund7
Dear Kirsten:
No, just "standard" HRT .... spiro and estrogen  ... started in March 2015
I know that Progesterone is a big contributor to breast development but I did not need or want it. 
My genetic makeup seemed to work well with the initial HRT.  In just a year of HRT I had almost a B-cup, at 2 years almost a C cup and at 3 years a full C-cup and thankfully I am at the 4+ year point of HRT and breast growth stopped... 
...or hopefully stopped! ???  ::)  ;)
I am more than happy with C-Cup and no larger... I did not want to inhibit my very active lifestyle with big bouncing breasts.

Hugs,
Danielle

Danielle,

That is an inspiring timeline. I have a feeling I will end up a C this year thanks to Jessica's progesterone thread/ food for thought.

After 30 days of P I find I'm getting tighter in a B- cup bra but havent got the tape measurement to prove it yet.

If things dont grow bigger than a B I will still be happy.

Interesting how Jessica got great reasults with P and yourself great results without P.

This is a great thread ! I think Linde's idea of a mini study is a good one too.

Yours, Kirsten x.

Sent from my SM-G930F using Tapatalk

In the last few days I have noticed that my breasts have definitely become rounder in shape.  Not the snoopy nose as of late.  And those areolae are continuing their increase in size.  I am nearly (if not actually there) a "C" cup.  I have felt different sensations in my breasts since starting Progesterone and expect even more development in the future.

Yay boobs! ☺️

Quote from: Jessica on May 07, 2019, 09:27:25 AM
In the last few days I have noticed that my breasts have definitely become rounder in shape.  Not the snoopy nose as of late.  And those areolae are continuing their increase in size.  I am nearly (if not actually there) a "C" cup.  I have felt different sensations in my breasts since starting Progesterone and expect even more development in the future.

Yay boobs! ☺️

@Jessica
Dear Jess:
This is terrific news regarding how things are changing for the better for you "topside."   
Hmmm, "Even more development in the future."
I am sure that many of your shirts and tops might be popping buttons very soon.

For me and my body size and activities that I am involved in I am very glad that I am at a C-cup and have not gotten any larger in the last year. 

Thanks for your report and for your thread here revealing your own progesterone experiences.
I will be eagerly looking for your future reports.

What about Lucy and Rhonda.... have their sizes evened out yet? ???

Hugs,
Danielle

I have a nice update on Lucy and Rhonda's big adventure on Progesterone.  At slightly more than two months on micronized Progesterone my bust dimension has increased a full inch @ an even 42 and rounder.  My areolae have increased from 1 1/4" to 2 1/4" on a defined mound with my nipples protruding out 1/4".
Of course I don't know if this has anything to do with Progesterone.

My band is 37" and my bust is 42" that makes my bra size 38D....
I think they are more of a "C" cup.

Hugs and smiles, Jess

Quote from: Jessica on May 19, 2019, 04:28:07 PM
I have a nice update on Lucy and Rhonda's big adventure on Progesterone.  At slightly more than two months on micronized Progesterone my bust dimension has increased a full inch @ an even 42 and rounder.  My areolae have increased from 1 1/4" to 2 1/4" on a defined mound with my nipples protruding out 1/4".
Of course I don't know if this has anything to do with Progesterone.

My band is 37" and my bust is 42" that makes my bra size 38D....
I think they are more of a "C" cup.

Hugs and smiles, Jessi

Wow!  That is impressive.  Congratulations. 

Chrissy

Quote from: ChrissyRyan on May 19, 2019, 04:36:54 PM

Wow!  That is impressive.  Congratulations. 

Chrissy

☺️

Quote from: Jessica on May 19, 2019, 04:28:07 PM
I have a nice update on Lucy and Rhonda's big adventure on Progesterone.  At slightly more than two months on micronized Progesterone my bust dimension has increased a full inch @ an even 42 and rounder.  My areolae have increased from 1 1/4" to 2 1/4" on a defined mound with my nipples protruding out 1/4".
Of course I don't know if this has anything to do with Progesterone.

My band is 37" and my bust is 42" that makes my bra size 38D....
I think they are more of a "C" cup.

Hugs and smiles, Jess

Somehow the bra size calculators are operating in fantasy land!  I have some 40 B that fit nicely, and I have some 40 B that have cups large enough to do the daily grocery shopping with, and still have my boobs nicely packed away in them!