Susan's Place Transgender Resources

Hello,
I've been taking androcur (cyproterone or siterone) for about eight months and have not reached castration levels yet... The strange thing is that testosterone keeps raising when I raise my dosage. I started with [removed dosage] for a month and I was near castration levels. Then my doc advised me to raise the dosage (to achieve womens' testo) to [removed dosage] for two months and then my testo raised. We did raised the dosage more and same results, my testo did raised more. My doc advices me to be patient...
Have anyone experience something similar? Taking low dosage for some time and have better results and then raise the dosage and have the opposite effect???

you'll have to discuss it with your prescribing physician, it sounds to me like a biochemical feedback loop, a reaction to reduced androgen levels.

Hi,

Your male body will react to the fall in T and start to produce more. Its a defence mechanism. After a while it may reduce, increasing dosage may not be the answer. I not sure your endo is looking at the whole picture, I have a good consultant and seems to know what he's doing. I was at another clinic and they never told me about Decapeptied. Mine never came down until I was prescribed Decapeptied injections that shuts off the process from the brain (now I'm just brain deed, lol). Sorry just my humour.

Stardust

Quote from: stardust on April 12, 2010, 02:43:39 AM
Hi,

Your male body will react to the fall in T and start to produce more. Its a defence mechanism. After a while it may reduce, increasing dosage may not be the answer. I not sure your endo is looking at the whole picture, I have a good consultant and seems to know what he's doing. I was at another clinic and they never told me about Decapeptied. Mine never came down until I was prescribed Decapeptied injections that shuts off the process from the brain (now I'm just brain deed, lol). Sorry just my humour.

Stardust

I asked him if it might be a body feedback reaction but he just says to be patient.  I wonder how can I get diagnosed for bad reaction....

I never had that happen to me personally (mine dropped like a rock). But, I have heard of the T rising in some people. I know one girl, for sure, who had the same thing happen, then tried spiro, then tried both, and continued to have problems with rising T (until she got srs, of course). I'm not sure why it happens to some people and others not. Everyone seems to be a little bit different when it comes to the levels, how far they drop and how long they take to drop.

Are you a male to female transsexual or just looking to be castrated? I know there are a lot out there that just want to lower their T. Are you taking estrogen? Estrogen could help overpower the T in conjunction with whatever T-blocker you are using.

Quote from: Dana Lane on April 12, 2010, 06:25:57 AM
Are you a male to female transsexual or just looking to be castrated? I know there are a lot out there that just want to lower their T. Are you taking estrogen? Estrogen could help overpower the T in conjunction with whatever T-blocker you are using.

This time I just want to be castrated. I know that if I add estrogen (I would like in the future), my T will get lower but I'm not ready to face the feminizisation results yet, I have not informed people around me that I take hormones.

Quote from: mantonis on April 12, 2010, 01:45:01 AM
Hello,
I've been taking androcur (cyproterone or siterone) for about eight months and have not reached castration levels yet... The strange thing is that testosterone keeps raising when I raise my dosage. I started with [removed dosage] for a month and I was near castration levels. Then my doc advised me to raise the dosage (to achieve womens' testo) to [removed dosage] for two months and then my testo raised. We did raised the dosage more and same results, my testo did raised more. My doc advices me to be patient...
Have anyone experience something similar? Taking low dosage for some time and have better results and then raise the dosage and have the opposite effect???

Same thing happened to me on Zoladex. I got awful side effects such as continued erections!

Try taking a different anti- androgen as different anti - androgens work differently on different people. cyproterone works fine with me but it might not work for someone else.

OK, took me a little while to track this down on another site that i frequent.
This extract is NOT from a doctor but may help to explain your situation.
As Flan said though, discuss this with your doctor.

"Cyproterone works by blocking the androgen receptors. It also appears to the

body to be an androgen so the body shuts down production of sex hormones because

it believes it has enough. Cyproterone also shuts down the enzyme pathways that

lead to testosterone production. This is why cyproterone is very effective for

MOST people however, by blocking the enzyme pathways it is possible in some

people who are predispositioned to it, to have a dramatic RISE in hormone

precursors ( 17 alpha-hydroxypregnenolone and dehydroepiandrosterone ), which

also have weak androgen action. If the dose is too high or for some other reason

( like taking progesterone ) these levels get high enough it can cause some

degree of masculinization to continue, such as body hair and other issues."

From my own research on cypro, less is more, so increasing your dose may only make your situation worse.

SEEK MEDICAL ADVISE!!

Shelly
xx

Good advice and post Shelly!

Quote from: Naturally Blonde on April 12, 2010, 02:00:52 PM
Good advice and post Shelly!

I'm so confused with all these. I cannot post my dosage but the one that I took when I was on almost on castration levels was way to little, to castrate me... Anyway I will insist my doctor to check it more and not just raise the dosage.
One more thing. I almost do not have anything to ejaculate, this happened gradually. Nothing comes out, just a small drop after some seconds of ejaculation.

I have had a similar effect. When I first started cyproterone acetate my testosterone levels plummeted. Then after a year they were up again , so my dose was increased and my libbido has gone up considerably, so must be the testosterone going up as well. Going to get a blood test in about a month to see if upping the dose has helped at all.

Have you added anything else to your HRT regime or any changes to other medication dosages Aruna?

I'm interested in Spiro but I can't get it here over in the U.K. Likewise I thought Androcur was banned over there in the USA.

Quote from: Naturally Blonde on November 26, 2013, 04:48:15 AM
Likewise I thought Androcur was banned over there in the USA.

In the US it's not as much banned as simply not FDA approved which is another way of saying not allowed but the DEA won't bust down doors over it unless a company markets it.

(by the way, best to not assume the nationality of a poster)

I can't get any form of anti-androgen on prescription over here in the U.K. I used to get my anti-androgens on prescription but my present GP refuses to give me a prescription. I am also attending a GIC but they are unhelpful also. So I have to get my anti-androgens either from friends or the internet. Ironically I can only get Androcur.