Susan's Place Transgender Resources

Community Conversation => Transitioning => Hormone replacement therapy => Topic started by: Carolina1983 on April 11, 2012, 09:27:40 AM

Title: Patch, pills or gel?
Post by: Carolina1983 on April 11, 2012, 09:27:40 AM
Hi :).


So I am pretty excited because I am due to start HRT in May :D, it feels so good to be so close.


But I am thinking about whats the best method to use? Patches? it seems like a good thing because you dont have to change the patch more than 2 times a week. But I am wondering if it is easy for them to fall off? nobody that I know use patches so if someone here got experience I would be very happy to know :).


Pills seems to be pretty bad for the liver etc? I feel like I want to stay away from them actually.

Gel? good or bad?


Any input is welcome :).
Title: Re: Patch, pills or gel?
Post by: Kelly J. P. on April 11, 2012, 09:43:53 AM
 People seem to prefer shots, as do I... but pills are probably my second favourite, and seem to be the second-most effective.

Of course, the effectiveness of all of them is the same, at least in theory.
Title: Re: Patch, pills or gel?
Post by: Bexi on April 11, 2012, 09:53:27 AM
A transwoman I know uses the patches and she said she was surprised at how durable they were. Out of curiosity, she kept one on until it began to fall off and said it had managed to remain attached for over two weeks!
Title: Re: Patch, pills or gel?
Post by: Constance on April 11, 2012, 09:56:09 AM
I had good results with estrogen patches, but they were prone to falling off. I bought large bandages to hold them in place.

But, the adhesive on the patches began to give me a rash, so I'm on oral estrogen.
Title: Re: Patch, pills or gel?
Post by: Bird on April 11, 2012, 10:30:54 AM
Gel is expensive, but it is safer to your health and easy to use. I like it.
Title: Re: Patch, pills or gel?
Post by: Carolina1983 on April 11, 2012, 11:10:39 AM
Thanks for the replies so far :).

The reason why I am not asking about shots is that I freak out by needles :P.


I am currently leaning towards patches but I am still open to other methods.
Title: Re: Patch, pills or gel?
Post by: Maja.V on April 11, 2012, 11:39:50 AM
People put too much emphasis on the effects of pills on one's liver. If you're a healthy person with no predispositioned illnesses regarding your inner organs, you're going to be fine.

Micronised estrogen pills can also be taken sublingually, bypassing the liver.
Title: Re: Patch, pills or gel?
Post by: Alainaluvsu on April 11, 2012, 09:39:35 PM
I do pills. I take E sublingually and my panels are all the same every time I take them. There's no reason to fear sublingual estradiol.
Title: Re: Patch, pills or gel?
Post by: Asfsd4214 on April 12, 2012, 09:41:13 PM
Quote from: Maja.V on April 11, 2012, 11:39:50 AM
People put too much emphasis on the effects of pills on one's liver. If you're a healthy person with no predispositioned illnesses regarding your inner organs, you're going to be fine.

Micronised estrogen pills can also be taken sublingually, bypassing the liver.

Strictly speaking it doesn't 'bypass' the liver, but semantics...

I feel this post needs to be repeated. The transgender hive-mind seems to have it in their head that the pills are super-hard on the liver, which is complete nonsense.

Yes any medication will likely put a little added stress on the liver. But unless you already have liver disease or some other risk factor this phobia of pills is really unfounded.

Some medications, like Cyproterone acetate, commonly used in transgender therapy, do have elevated risks to the liver. But estradiol is not one of them.

I take estradiol, spironolactone, a med for depression, and two more meds for multiple sclerosis, and usually acetaminophen (FAR harder on the liver than estradiol) to counteract the side effects of the other medications, and I used to drink excessively. My liver has been fine on every blood work I've done.

So this paranoia about taking pills and suddenly your liver dying is unfounded.
Title: Re: Patch, pills or gel?
Post by: MacKenzie on April 13, 2012, 12:32:18 AM
  You could try estrogen implants. They're tiny little pellets implanted into your body through a small incision. The pellets slowly dissolve into your blood stream for anywhere from 3 to 5 months. I think it's a little more expensive then the other methods but it bypasses liver functions and since it dissolves slowly your hormone levels remain consistent.

  I'm thinking about asking my doctor about switching to estrogen implants, currently i'm doing injections.
Title: Re: Patch, pills or gel?
Post by: Carolina1983 on April 13, 2012, 01:58:32 AM
Quote from: MacKenzie on April 13, 2012, 12:32:18 AM
  You could try estrogen implants. They're tiny little pellets implanted into your body through a small incision. The pellets slowly dissolve into your blood stream for anywhere from 3 to 5 months. I think it's a little more expensive then the other methods but it bypasses liver functions and since it dissolves slowly your hormone levels remain consistent.

  I'm thinking about asking my doctor about switching to estrogen implants, currently i'm doing injections.


Implants is something I did not know about but it sounds interresting indeed. Thanks :).



And regarding the pills. I have heard som many horror stories about pills and thats why I was so cautious about taking them :). I have talked to my doctor and it seems like you are right, it is not that dangerous as I first thought.


I still have to think this through for a few days before deciding though. But the comments here have been helpful. Thanks.
Title: Re: Patch, pills or gel?
Post by: KURTSII on April 13, 2012, 06:24:11 AM
Hi Carolina!

I am also a newbie to HRT. I did lots of reading online, making the decision to get my toes wet with Estrofem tablets.

I had read numerous articles that indicated the older you are, the less apt you are to achieve timely, satisfactory results. Also, finding any two sources of information that specified the same general timeline of results was next to impossible! Most simply noted that the onset would take months to materialize.

With that, I can tell you this:

I am 42. I began my faithful, daily regiment of Estrofem on Friday, March 23rd of this year. 

I had read that orals were indeed harsh on the liver, however permitting the dose to dissolve under your tongue spares the liver some of that hard work, permitting for a speedy introduction into the bloodstream. In this manner, Estrofem leaves no foul taste in my mouth. It's almost too perfect! : )

Today marks my third week of HRT. The past few days I have been near obsessed wondering if there was something going on in terms of breast growth...

Albeit, I am experiencing some degree of tenderness; but I am also experiencing a notable increase in volume... enough so that I am aware an occasional jiggle in my step, an unmistakeable perky protrusion in my side profile, and a definite increase (swelling?) in the size of the nipple themselves.

Last night, my spouse told me out of the blue that they were noticeably larger!!! That sent me into orbit! I am giddy almost beyond words!!!

With that, I have to relay that the 'older you are' expectations are either not very well researched, or genetics are playing the upper hand in my case... (my grandmother sported a very large bust, as did my mother, and my sister is no exception).

I hope I have given you something positive to think about!

Good luck with starting your HRT!


Love,
Kurtsii



Title: Re: Patch, pills or gel?
Post by: justmeinoz on April 13, 2012, 07:21:21 AM
My Endo generally prescribes the  Microgynon  pill as it is readily available, and has been around long enough for any side effects to be readily detectable.  I looked at the available info in my last job at a Pathology Lab, and am comfortable taking it. 

It is a low dose admittedly, but seems to be working extremely well.
Bodily changes are progressing nicely and I am quite happy with the results to date.

Karen.
Title: Re: Patch, pills or gel?
Post by: Jamie D on April 13, 2012, 01:58:02 PM
I am in my 50's and use a transdermal patch for low-dose estradiol, though that has been suspended for a few week due to a health complication unrelated to the hrt.

I am strongly considering add micronized progesterone to supplement and/or replace the estrogen, as a contingency, depending on my health.
Title: Re: Patch, pills or gel?
Post by: latingrl on April 13, 2012, 11:39:37 PM
Does any one on this forum know any Physicians in the Los Angeles area that can prescribe hormones. Also what I can expect to pay monthly.
Title: Re: Patch, pills or gel?
Post by: Carolina1983 on April 14, 2012, 12:02:37 AM
Quote from: KURTSII on April 13, 2012, 06:24:11 AM
Hi Carolina!

I am also a newbie to HRT. I did lots of reading online, making the decision to get my toes wet with Estrofem tablets.

I had read numerous articles that indicated the older you are, the less apt you are to achieve timely, satisfactory results. Also, finding any two sources of information that specified the same general timeline of results was next to impossible! Most simply noted that the onset would take months to materialize.

With that, I can tell you this:

I am 42. I began my faithful, daily regiment of Estrofem on Friday, March 23rd of this year. 

I had read that orals were indeed harsh on the liver, however permitting the dose to dissolve under your tongue spares the liver some of that hard work, permitting for a speedy introduction into the bloodstream. In this manner, Estrofem leaves no foul taste in my mouth. It's almost too perfect! : )

Today marks my third week of HRT. The past few days I have been near obsessed wondering if there was something going on in terms of breast growth...

Albeit, I am experiencing some degree of tenderness; but I am also experiencing a notable increase in volume... enough so that I am aware an occasional jiggle in my step, an unmistakeable perky protrusion in my side profile, and a definite increase (swelling?) in the size of the nipple themselves.

Last night, my spouse told me out of the blue that they were noticeably larger!!! That sent me into orbit! I am giddy almost beyond words!!!

With that, I have to relay that the 'older you are' expectations are either not very well researched, or genetics are playing the upper hand in my case... (my grandmother sported a very large bust, as did my mother, and my sister is no exception).

I hope I have given you something positive to think about!

Good luck with starting your HRT!


Love,
Kurtsii


Hi and thanks for sharing that :).

I am glad that you are experiencing such good results, I have also heard alot about the age thing. Especially that after 25 its going downhill =/, that can make me e little upset sometimes because I am now 28. At the age of 21 I was so close to take the step but unfortunately I tried to man up instead, yeah you can see how that went  :P.
Title: Re: Patch, pills or gel?
Post by: monica93304 on April 14, 2012, 02:19:59 AM
Quote from: MacKenzie on April 13, 2012, 12:32:18 AM
  You could try estrogen implants. They're tiny little pellets implanted into your body through a small incision. The pellets slowly dissolve into your blood stream for anywhere from 3 to 5 months. I think it's a little more expensive then the other methods but it bypasses liver functions and since it dissolves slowly your hormone levels remain consistent.

  I'm thinking about asking my doctor about switching to estrogen implants, currently i'm doing injections.

This is the method I will eventually settle on. Here's a link for you

www.odeamedical.com

It's not far from home, and I received a promt response to my questions by Dr. O'Dea himself.

Title: Re: Patch, pills or gel?
Post by: Jamie D on April 14, 2012, 02:47:12 AM
Quote from: latingrl on April 13, 2012, 11:39:37 PM
Does any one on this forum know any Physicians in the Los Angeles area that can prescribe hormones. Also what I can expect to pay monthly.

Any properly licensed doctor can prescribe medications.  If you follow "the book," you will need to consult with a therapist who will help you explore whether you have "gender identity disorder"and whether you will benefit from hormone therapy.

Start an internet search for "gender therapist" in Los Angeles.  I think you will find several in the Westwood (UCLA), West Hollywood, and Santa Monica areas.  You might even find physicians who practice "informed concent."
How much you might pay depends on your insurance coverage, if any, and what medications you are on.
Title: Re: Patch, pills or gel?
Post by: MacKenzie on April 14, 2012, 03:58:38 AM
Quote from: monica93304 on April 14, 2012, 02:19:59 AM
This is the method I will eventually settle on. Here's a link for you

www.odeamedical.com

It's not far from home, and I received a promt response to my questions by Dr. O'Dea himself.

Thanks for the info Monica, a friend of mine goes to him for her estrogen implants too. =P
Title: Re: Patch, pills or gel?
Post by: Dale on April 14, 2012, 06:41:26 PM
I do shot of E every 2 weeks and a pill subligually every night. Work great for me and easier on the liver
Title: Re: Patch, pills or gel?
Post by: Carolina1983 on April 25, 2012, 09:11:54 AM
So today I started. It is a patch that I am wearing. I think it takes a while to get used to because I am extremely focused on things that sit on my body that should not be there naturally and can get pretty sensitive about it.

But after a few hrs i start to get used to it, but I am very worried about the patch to curl or fall off :D, so I am pretty stiff att the moment :P.


Anyways it feels great to be on the right path :).
Title: Re: Patch, pills or gel?
Post by: Bexi on April 25, 2012, 07:47:00 PM
Quote from: Carolina1983 on April 25, 2012, 09:11:54 AM
So today I started. It is a patch that I am wearing. I think it takes a while to get used to because I am extremely focused on things that sit on my body that should not be there naturally and can get pretty sensitive about it.

But after a few hrs i start to get used to it, but I am very worried about the patch to curl or fall off :D, so I am pretty stiff att the moment :P.


Anyways it feels great to be on the right path :).
Hehe Awesome!

From what I'm aware, its quite durable. My afore-mentioned acquaintance said they end up feeling second nature and you don't realise you have them on. But i'd probably follow you're thinking and treat them carefully incase they fall off.

X
Title: Re: Patch, pills or gel?
Post by: A on April 25, 2012, 07:59:00 PM
The last I've read about gels was "uneffective", but I don't know if the info was reputable or anything. Patches seem good to me; it's the method that delivers hormones in a way most similar to ovaries - as small dose, continuously. Some doctors, and me too, think that it's quite an advantageous method.

Apart from that, I think pills would be my second choice. Easy, invisible ("hey, Mary, what's that big bandage on your hip?"), cheap and simple. That's what I have.

As for the patch falling, it shouldn't happen in theory... but it does happen to some, depending on skin type. If it comes off, ask your pharmacist for a tip. Maybe just a little medical tape would do the trick. (I don't know if a patch that is held by tape would still deliver its full does, though.)
Title: Re: Patch, pills or gel?
Post by: auburnAubrey on April 25, 2012, 08:58:43 PM
I'm on the estrodot patch, and work out until I'm as wet as i am in the shower...... it has never fallen off.  I am also a firefighter, so I work hard, and it has never fallen off.  I use two a week.  One for three days, one for four.  There are 8 in the box.

Also, transdermal estrogen has been shown to be less of a clot risk than pills.  Which was a benefit for me.

My endo is fantastic.  His approach is simple... stop the testosterone, and your body won't need high levels of estrogen.  I'm on Lupron Depot, which is expensive  as hell... (I get it from Canada for much less than the US).  Had great results, even at 42 years old.  I read a lot about HRT before starting, and never saw anything about Lupron.  Of course, there's also the orchi surgery... that will also stop your test, which will lower your need for the amount of estrogen.

Health wise, it's a great option.  Stop the testosterone, lowers the amount of estrogen to cause feminization.  Makes sense.

But back to the patch... never had a problem, and I am very, very active.
Title: Re: Patch, pills or gel?
Post by: Jamie D on May 01, 2012, 01:43:28 AM
If there is a problem with the patch falling of, some people put a waterproof bandage on top of it.

I used a once-per-week patch, that got itchy after about 5 days.  So I just peeled it off and moved it.
Title: Re: Patch, pills or gel?
Post by: janis on May 07, 2012, 12:30:37 PM

     Hi,
      My doctor percribed estradiol gel for me// how effected is it, doe's it really work?
     Thanks
     janis
Title: Re: Patch, pills or gel?
Post by: Carolina1983 on May 07, 2012, 02:27:49 PM
Ok so now I am 2 weeks in. The first patch was a pain to keep on because I did not know where to place it.. But now I have found a spot that is perfect for the patch :D (finally), I will keep the patch for a while longer but in the future I will switch to something else. It would be nice with a implant to be honest.


Anyway here is the thing that makes me somewhat stunned..... I am just 2 weeks in but my skin already changed to the better a week ago. How is this possible? even my wife noticed because I am smooth like a baby. But I expected it to take atleast 1,5 months or so before I would notice any changes.

Also my sexdrive is zero. And the thing downstairs feels... Hmm I am not sure how to explain it but its like the wires are cut off, my brain doesnt connect to it.. But I am not complaining :), it feels good actually.
Title: Re: Patch, pills or gel?
Post by: A on May 07, 2012, 05:16:05 PM
janis: I PERSONALLY don't think gel is the most effective delivery method; however some have had good experiences with it. But either way, it does have the desired effects; only, if I'm right, not as much as patches or pills.

Carolina1983: It is possible. I noticed the exact same thing (though I wouldn't say I had THAT much of a change with my skin). However, you might be unconsciously seeing more effects than what there actually is through placebo effect / wishful thinking, and it can go for anyone, wife included, as long as they know you're on HRT.
Title: Re: Patch, pills or gel?
Post by: janis on May 08, 2012, 01:44:21 PM


    Hi Carolina,
      Thanks for the information, I do get a little
    headache from it, I hope that's the worst that
    happens.
      Hugs,
      janis


Title: Re: Patch, pills or gel?
Post by: Carolina1983 on May 08, 2012, 02:05:08 PM
Quote from: janis on May 08, 2012, 01:44:21 PM

    Hi Carolina,
      Thanks for the information, I do get a little
    headache from it, I hope that's the worst that
    happens.
      Hugs,
      janis

I also got a headache but it dissapeared just a few days ago. Sure I can get it for some short periods but it is not like it was the first week :).

I wish you all the best :)..

Hugs
/C
Title: Re: Patch, pills or gel?
Post by: Bird on May 10, 2012, 10:37:10 AM
Gel is a effective method just as patches are. If a guy asks you what is the patch in your butt, tell him it is your chosen birth control method.
Title: Re: Patch, pills or gel?
Post by: janis on May 17, 2012, 09:11:23 AM


     Hi Again,
       A little update on the gel which I am taking, It seems I feel more comer
     and for some reason I am not crying like I was before.
     Hugs,
     janis
Title: Re: Patch, pills or gel?
Post by: A on May 17, 2012, 09:16:13 AM
More comer?
Title: Re: Patch, pills or gel?
Post by: Carolina1983 on May 17, 2012, 11:22:21 AM
More calmer? that the only guess that I can come up with :).


3 weeks in now and the thing that I have noticed are.

1. Softer skin and the pores are a little smaller now.

2. Much calmer although I can swing from happy to sad in a second :P

3. My breasts are looking a tad different and I also asked my wife to see if it was only my imagination but no. The have changed shape and the area around the nipples are a bit raised (I dont know any better way to describe it).


So I am happy so far :), the paches seem to work and I found a good position for them so that they do not fall of as easy as they did the first week.
Title: Re: Patch, pills or gel?
Post by: Bexi on May 17, 2012, 02:41:26 PM
The mood swings make life ... interesting :P
X
Title: Re: Patch, pills or gel?
Post by: JohnnieRamona on May 17, 2012, 02:49:02 PM
Congrats Carolina! I'm very happy for you (and a tad jealous).

I haven't seen an endo yet, but in terms of pills- what variety of estrogen pills should I request when I get to that point? I'm thinking I'll try to get my endo to put me on spiro and estrogen, and pills sound like the cheapest option.
Title: Re: Patch, pills or gel?
Post by: A on May 17, 2012, 05:52:39 PM
Pills are the second cheapest, actually. Injections supposedly cost next to nothing. But I don't recommend injections.

Anyway~  you don't have to worry about that, really. Your endo should know what they'll prescribe. But in case you do worry, the usual medications are:

-Conjugated estradiol (often sold under the brand name Estrace® for pills, or Estraderm® for patches)
-Spironolactone or cyproterone acetate (often sold under the brand name Androcur®)
Title: Re: Patch, pills or gel?
Post by: janis on May 18, 2012, 01:08:20 PM


  Hi,
   Sorry about the mispelling,more calmer
  Hugs,
  janis
Title: Re: Patch, pills or gel?
Post by: jenn90210 on May 19, 2012, 12:46:26 AM
Quote from: A on May 17, 2012, 05:52:39 PM
Pills are the second cheapest, actually. Injections supposedly cost next to nothing. But I don't recommend injections.

Anyway~  you don't have to worry about that, really. Your endo should know what they'll prescribe. But in case you do worry, the usual medications are:

-Conjugated estradiol (often sold under the brand name Estrace® for pills, or Estroderm® for patches)
-Spironolactone or cyproterone acetate (often sold under the brand name Androcur®)

why u dont recommend injections?
Title: Re: Patch, pills or gel?
Post by: A on May 19, 2012, 12:18:12 PM
Don't take my word as a fact - injections are subject to controversy and debate, and neither side has any actual proof to invalidate the other. So, 1. most of what I say is contestable; 2. even doctors cannot give 100 % certain information. Nevertheless, my opinion can hardly compare to the expertise of one who has experience in the endocrine treatment of transsexuals and has studied medicine. So definitely listen to your doctor.

However, my reasons for believing that injections are not a good idea are (to avoid any confusion, those are merely organisational frames; I am not quoting anyone):
Quote
They consist in a huge dose administered once a week, and count on the injection site (intramuscular, or fatty tissue, I think) to differ the actual diffusion of the product in the blood. But if you don't do it right or -something- goes wrong, there's a slight chance that it might not be really differed, and everything would be released in your blood very quickly, which carries risks. If you do it right, the risk is negligible if not absent, but -I- would personally not trust myself.
Quote
Even though the diffusion of the product is a bit differed, it still spreads hormones around your body much faster than any other delivery method, at a much higher dose, which causes a steep spike in your hormone levels, followed by a large trough until the next dose - since it's administered weekly. So your hormones regularly go both way higher and way lower than the regular levels.

But it has been shown (mentioned here (http://www.gires.org.uk/assets/Medpro-Assets/Progesterone.pdf)) that in the early pubertal natal female (at the stage when most secondary characteristics develop, actually, such as breasts), oestrogen levels increase very steadily, without spikes: it's before the start of menstruation, in average.

As steady levels of oestrogen is how it works in the natal female, and it seems to work well, it makes sense to me that it should be how it works best in trans females, too.
Quote
And still on the very up-and-down pattern that injectable oestrogen creates... Well, it's just extrapolation, but apart from treatments where shock is what we're looking for (e.g. chemotherapy), in medicine, it's generally common wisdom to research the smoothest curves of serum levels and effects, to try to make them look like a straight line, no?

I just think it feels wiser, safer and most effective to go for a steady approach, too.
Quote
Moreover, since hormone levels go up and down a lot, by the end of the week, your levels should be very low. At that time, you have a significant level of neither estradiol nor testosterone, which is commonly regarded as bad. It's for short periods, but it happens very repeatedly, right? Maybe it has bad effects in the long term.

And also, going up and down so much with hormone levels might cause side effects, such as mood swings. I don't know if it does, but it seems logical to me that it would.
Quote
One of the main theoretical advantages cited for injections is that contrarily to pills, since the product is directly released into the blood stream, it does not have to undergo a first passage through the liver, which, I think, would reduce efficiency (I think it was mentioned somewhere that not all of the product actually made it into the blood stream), and that would mean that maybe depending on the person, when taking pills, very high doses might be required.

Furthermore, pills are supposed to make the liver work especially hard, which is not good. For patients who are older and/or have a lifestyle that already strains their liver, such as drinking or being on other medications, it poses a risk of premature liver dysfunction, which is a very serious thing.

It's also possible (pure non-expert extrapolation) that even in the absence of risk factors, it might wear it out faster, which might affect one's life expectancy, or cause higher cholesterol/etc. levels despite the consumption of fat being all but excessive, for example.
________________________________________________

Those were the potential disadvantages of pills, the most widespread delivery method, and I do not deny them for one second. However, injections are not the only delivery method that has the advantage of direct blood stream spreading.

For one, simply taking estradiol pills sublingually (if the pills make it possible; I think it depends on the brand) makes part of the dose go directly into the blood stream (what you don't accidentally swallow with saliva and doesn't stay with the remains of the pill once you swallow, actually, and thatcan't be completely eliminated, right?)

There are also transdermal patches (and gels, but I haven't read a lot of good about those, and in all logic, they're probably not any steadier than pills), which as a bonus give you almost 100 % stable hormone levels, since they release them in real time, second by second, just like ovaries would. Pills are more stable than injections (2 relatively low doses a day), but not nearly as much as patches.

The only disadvantage I can see to patches, apart from the fact that they are, I think, twice the price of pills, is perhaps an allergic reaction to the adhesive (and I think there is more than one brand which don't all use the same, so you can probably get away with an allergy), or perhaps a skin on which stuff just doesn't stick. But even in that case, I'm sure that with a pharmacist, one could find a way to make it work with medical tape and whatnot.

Ah, there's also the fact that the patch could be seen, but since it's put in areas that are generally hidden by clothes, my belief is that if anyone is close enough to you to look there, they're also close enough to see your pills or injectable preparation and syringes.
Quote
On a less medical standpoint, I also find injections to be the least practical delivery method. They're done once a week, so daily routine won't help to remember it. -I-, at least, would very easily forget a weekly thing like that. I have plenty of examples in my life. (Hello, dusty floor!)

Also, some others find it easy and quick, but I would find it really tedious to have to bring out the product into a syringe and inject it, or have to go see a doctor/nurse weekly, or something.

And that's entirely putting aside my fear of needles as well as my very high sensibility to pain - especially that kind of pain. I might just faint whilst trying to do it, which is probably dangerous, and in my fear, I think I could easily make a mistake like injecting myself with an air bubble for instant death, or punctioning the wrong place, or...
Quote
There is also the fact that some countries have not licenced injectable estradiol for prescription and use there, such as the United Kingdom and maybe Canada (I know doctors here don't prescribe it, but I'm not sure if they could if they wanted to). It's a little bit of a sophism to say this and rely on their "authority", but I don't know... if they have no problem whatsoever with pills, despite their proven risks, and transdermal patches, it seems unlikely to me that they wouldn't allow injectables without any valid reason.

There's a chance that it's just because the safeness of injections just haven't been proven enough yet for some governments to permit them; that it's just a precaution. But I haven't heard of such a thing, and it seems unlikely to me, since it's everything but a brand new drug.
Quote
Some people report that upon starting injections, their effects went way up. Here is what I told another member about it, and I don't think I'm wrong:
Quote from: A on May 16, 2012, 04:53:33 PM
[...]
Also, it certainly doesn't fit all cases; maybe not even the majority, but in many cases where people reported having had much better results after starting injections, it was often either:
-They hadn't been on HRT for very long, and it's reasonable to think that the same spike of change could have happened with just any other delivery method. It does happen often, after all, that after a few weeks/months on a steady dose of hormones or after a pill dose increase, eventually levels reach a point where change suddenly starts to happen. It could just be a coincidence.
-Their hormone levels and pill dosage weren't correctly adjusted, so of course, when they started injections of a huge dose, changes appeared. But in those cases, who knows if a higher dosage with another delivery method wouldn't have done the exact same?

I'm not saying that the effects of injections are a fallacy, and that all results were biased, but I still think you should be cautious of what your hear about. It's like that with many things, really.
[...]
Quote
The very low cost of injectable estradiol is a big argument for some. But I think that the vast majority of people can afford pills which, whilst more expensive, are still pretty cheap: on my latest purchase, 0,54 $ per tablet; 32,40 $ for the 60 a month I take, all that, I think, after taxes (not sure though since taxes aren't displayed on medication receipts) and before insurance.

Of course, there are many who live in a poverty I cannot even imagine and try to save every penny they can for other things such as surgery, so I can't entirely rule out cost as a factor. After all, I know little of such money problems, since most prescription drugs are 80 % paid for by the government, and the total cost per month are limited (everything's free past that limit).
Quote
Some claim that since injectables have a much higher maximum in the serum level curve, it could help "kick changes off" by defeating some kind of "resistance" with a high dose, or that a high dose might condition cells to be more receptive to oestrogen. I can't rule that out, since as I said, there is probably at least some basis for testimonies in favour of injections.

But honestly, I think that since the number of receptors is fixed (right?) and I don't really see what sort of "wall" there could be to beat, I don't know. I don't really understand how it could be that way.
...Phew! So... You have a full "essay or my opinion" on HRT delivery methods. The bottom line is:

Why use a relatively controversed delivery method whilst you could be using one of the other methods that are pretty much prescribed everywhere and recognised as safe and effective (outside specific conditions, huh) by all doctors (that I have heard of)?

I hope this was helpful.
Title: Re: Patch, pills or gel?
Post by: janis on May 23, 2012, 03:53:11 PM


    Hi Again,
       I do not know if  I am fooling myself, but my right breast
    been feeling kind of funny., I am happy about it, if it's
    the gel is working.
    Hugs, janis       
Title: Re: Patch, pills or gel?
Post by: Carolina1983 on May 23, 2012, 04:24:42 PM
:) that is great Janis.


Fast changes seems to happen because my breasts are growing too :o, my doctor was kind of surprised when she looked at me 2 days ago.


I really hope that this trend will continue.


Oh sorry I must stop talking about myself :D.

Keep us updated Janis.
Title: Re: Patch, pills or gel?
Post by: janis on May 31, 2012, 07:48:02 AM


       Hi Again,
         I been on gel for the last month, but I have been having a lot
      of itching on my nipples., could this of concern?
         I read it could be a sign of cancer, could this be for real?
       Hugs, janis
Title: Re: Patch, pills or gel?
Post by: A on May 31, 2012, 08:10:16 AM
I personally call this a sign of growth. Cancer doesn't generally develop so quickly and it's more than unlikely to have breast cancer with male hormone levels. It's normal. Just give them a lot of moisturisers and protect them from friction. For me, it subsided after less than a week.
Title: Re: Patch, pills or gel?
Post by: janis on June 06, 2012, 09:19:35 AM


     Hi Again'
       Had my blood work done, my t level was under 150,
     is this good or bad?
     Thanks,
     janis
Title: Re: Patch, pills or gel?
Post by: janis on July 04, 2012, 08:19:02 AM


        Hi Again,
          Been a the gel for almost two months now, I can truly say
        I do see a little more results' my skin is feeling much softer
        and my nipples are sticking out a little more? Will keep
        you updated//
        Hugs Janis
         PS. Happy Birthday America   
Title: Re: Patch, pills or gel?
Post by: janis on July 05, 2012, 03:03:19 PM


     Hi,
      I went shopping today, bought a pair of Capri pants, and then
    went to Macy's and bought my self some spandex.,I do have to lose
    some weight. So I really think the hormones are working and I
    feel happy about it with no embarrassment going in the women's
    department.
     Hugs Janis,
     PS. It feels really Good to feel Good
Title: Re: Patch, pills or gel?
Post by: Carolina1983 on July 05, 2012, 06:00:27 PM
Yeah it feels wonderful to have the right hormones in the body..


I also have my moments of joy now which I never had before :).


However I am not passable which annoys the crap out of me at the moment. I also long for the laser this autumn because the shadow gets darker and its a pain because it wont go away :(.


Anyway its good to hear that you feel good :).



Had any mood swings btw? I am a bitch according to my wife :P. And she is pregnant so you can just imagine how loud it can get in this house :P.
Title: Re: Patch, pills or gel?
Post by: Bexi on July 05, 2012, 06:27:35 PM
Quote from: Carolina1983 on July 05, 2012, 06:00:27 PM
However I am not passable which annoys the crap out of me at the moment.
Join the club! I really really reeeaaallly want to go out wearing what I want, without a care in the world but I know the trouble caused would not be worth it. I just have to wait for the hormones to do their jobs  :P Or else get super-good at make-up :laugh:!

Quote from: Carolina1983 on July 05, 2012, 06:00:27 PM
Had any mood swings btw? I am a bitch according to my wife :P. And she is pregnant so you can just imagine how loud it can get in this house :P.
Congratulations on your expectancy  :) And I had strange mood swings too - going from happy to crying to angry! They were even worse if I had any alcohol too! So much so that I've actually stopped drinking entirely (its tough lol!)
X
Title: Re: Patch, pills or gel?
Post by: janis on July 10, 2012, 09:40:20 AM


    Hi Again,
      Congratulation on your up coming arrival, Carolina, He or She will be a real joy.
    Also since being on hormones, my finger nails have been splitting,
    is this very natural?
    Hugs, Janis
Title: Re: Patch, pills or gel?
Post by: Carolina1983 on July 10, 2012, 07:02:14 PM
Quote from: janis on July 10, 2012, 09:40:20 AM

    Hi Again,
      Congratulation on your up coming arrival, Carolina, He or She will be a real joy.
    Also since being on hormones, my finger nails have been splitting,
    is this very natural?
    Hugs, Janis


Thank you :).


And yeah I have the nailproblem too =/. I have broken my nails alot lately, I need to be more careful.
Title: Re: Patch, pills or gel?
Post by: rachl on July 13, 2012, 06:09:21 PM
I'm having trouble finding this information; I hope someone can help.

People say that the "micronized" version of estradiol can be taken sublingually, but my pharmacist says 'no'. Is she just wrong? I think that Estrace is the brand name that they have here (purple pills). I've read that this is, in fact, micronized.
Title: Re: Patch, pills or gel?
Post by: Carolina1983 on July 14, 2012, 03:58:50 PM
Just got it confirmed by 2 others.  My hair that I lost over the years when T was raging feely in my body is now growing back :D *happy happy* I cant believe that its really happening.
Title: Re: Patch, pills or gel?
Post by: A on August 03, 2012, 02:30:44 PM
Quote from: rachl on July 13, 2012, 06:09:21 PM
I'm having trouble finding this information; I hope someone can help.

People say that the "micronized" version of estradiol can be taken sublingually, but my pharmacist says 'no'. Is she just wrong? I think that Estrace is the brand name that they have here (purple pills). I've read that this is, in fact, micronized.
If the pharmacist says no, it's probably no. Ask another to make sure if you want, but don't put Internet over a professional in terms of reliability.
Title: Re: Patch, pills or gel?
Post by: rachl on August 03, 2012, 05:56:00 PM
Well, I have one pharmacist saying 'no', and another saying 'yes.' I think that pharmacists are so used to people taking that medication orally, that it never occurs to them that someone might want to take it SL.
Title: Re: Patch, pills or gel?
Post by: Oriah on August 03, 2012, 06:13:31 PM
I prefer pills, but sublingual as opposed to swallowing.....more effect from a smaller dose....no digestion, just direct into the bloodstream

Title: Re: Patch, pills or gel?
Post by: delta9 on August 03, 2012, 06:30:19 PM
I'm thinking about using patches instead of pills
Title: Re: Patch, pills or gel?
Post by: Katherine on August 19, 2014, 07:47:37 PM
Hi, I've been using Oestrogel (17B Estradiol) for six months.  A couple months in my breasts were sensitive, a little sore.  About 4 months in my breasts were a bit larger and have more volume.  My left breast is a bit larger than my right.  By then, when talking to my coworkers, they had, and still do, have a tendency to look at my breasts  :o
I'm more careful right now with the types of shirts I wear.  I've been on spiro for about six weeks and p for three weeks.  A couple months ago my breasts stopped being as sensitive, no soreness.  Since I started spiro and p, they are more sensitive again, and my nipples a bit sore to the touch.  My skin appears to be softer.  Also, I'm actually losing some body fat, which is supported by the fact that I've gone from about 190lbs to 179lbs.  My breasts are large enough to cup in my hands.  When I hold my hands about my head, they protrude enough to be noticeable.  Essentially, my measurement below my breast (for band size) is 36, and my measurement across my breasts (nipples) is 39.  As far as fat redistribution, I can't really tell.  Hugs.
Title: Re: Patch, pills or gel?
Post by: Blue Senpai on August 19, 2014, 07:51:54 PM
Going to be using injections for testosterone even though I'm not sure if I'll be able to self-inject.
My older brother is a doctor so he can help me out with injecting it in my thigh muscle...