I'm already androgen insensitive in most places except that I do have facial hair growth (albeit weaker than normal) and receding hair (no top balding), and feel that my estrogen levels are naturally higher, as well. Whenever something aggravates me, and I just let it go until I'm ready to burst, that rush of testosterone doesn't make me feel empowered in the slightest. I feel shaky and I cry. When I had a kidney stone years ago I was given a shot of morphine, and it gave me the same feeling... panic, shakiness and tears. So, what would happen if someone with my chemical makeup ended up trying to supplement with testosterone? There had to have been clinical trials of doctors thinking they can "cure" transgender people and discovering adverse reactions. I would think I'd just become more erratic and even more dysphoric. I have no interest in it at all, but it's fascinating to ponder on.
This is exactly what my wife wished for me to do. Luckily, the endo did not agree.
I took testosterone and found much of it converted to estradiol via the enzyme aromatase.
The testosterone had a small effect, but the estradiol was very effective. After six months I had the start of some very nice breasts.
Randi