Susan's Place Transgender Resources

Community Conversation => Transitioning => Hormone replacement therapy => Topic started by: Wynternight on September 15, 2014, 08:41:51 PM

Title: Day Five on Progesterone
Post by: Wynternight on September 15, 2014, 08:41:51 PM
I started progesterone Thursday and so far I've noticed a definite leveling in my mood again. I had had that affect the first few days on estadriol before sinking into a deep depression on day four that lasted about a week. I'm feeling much more calm since starting the progesterone. About 30-45 minutes after taking it I start to get get lightheaded and a bit drowsy. That feeling continues and eventually turns into a powerful euphoria that remains for a good few hours before settling down into a kind of languid state. It was hard to sleep the first few nights as the euphoria was kind of distracting (wheeeeeeee!!) but last night I slept really well. So far so good. :)
Title: Re: Day Five on Progesterone
Post by: Jessica Merriman on September 15, 2014, 10:12:06 PM
Told you it was good stuff! *giggle* Just wait till the girls get a good amount onboard!!  ;D
Title: Re: Day Five on Progesterone
Post by: Wynternight on September 15, 2014, 10:29:52 PM
Quote from: Jessica Merriman on September 15, 2014, 10:12:06 PM
Told you it was good stuff! *giggle* Just wait till the girls get a good amount onboard!!  ;D

Ayep, you definitely did!!  ;D
Title: Re: Day Five on Progesterone
Post by: KayXo on September 16, 2014, 12:36:56 PM
Quote from: Wynternight on September 15, 2014, 08:41:51 PM
About 30-45 minutes after taking it I start to get get lightheaded and a bit drowsy. That feeling continues and eventually turns into a powerful euphoria that remains for a good few hours

Love that part! Usually, for me, it starts anywhere from about 30 minutes to 2-2.5 hours after taking it. Depends on what and how much I eat prior to taking it. I wish it lasted a little longer though, I do take it twice daily. Around the same time these feelings hit me, my breasts also perk up, the areolas become larger, like a mound over the breast. It's WAYYY cool! :) I think I'm addicted to progesterone. :(
Title: Day Five on Progesterone
Post by: Eva Marie on September 17, 2014, 01:07:06 AM
I never know what progesterone is going to do me. I've had experiences ranging from weaving in and out of traffic cussing at the top of my lungs to weeping in my office and hoping no one came by to.... no effect whatsoever. In my experience progesterone is a very weird drug, albeit with some very nice physical effects if you can get thru the emotional stuff.
Title: Re: Day Five on Progesterone
Post by: Jessica Merriman on September 17, 2014, 01:14:31 AM
Quote from: Eva Marie on September 17, 2014, 01:07:06 AM
Iif you can get thru the emotional stuff.
It has no &%^emotional stuff at all so quite say.. I simply adore that blouse sweety, it looks so wonderful.....Effects? It has no &%%# bad effects and I hate how some people like to.....Feel like baking some cookie? I love to eat them hot and fresh in front of the fireplace at.....&%^$%$%$ it has no emotional effects! How could you even insinuate Progesterone causes any......Look at the cute kittens! OMG they are so adorable! They look like little fluffy balls of......So, no more comments about Progesterone causing any *^&% *^&% emotional effects becau......Oh sweetie, I am so glad your name change is official. I bet it feels so..Where am I?  ;D ;D ;D :laugh: :laugh: :laugh:
Title: Day Five on Progesterone
Post by: Eva Marie on September 17, 2014, 02:10:11 AM
LMAO!!! :)
Title: Re: Day Five on Progesterone
Post by: Newgirl Dani on September 25, 2014, 07:59:39 PM
Quote from: Jessica Merriman on September 17, 2014, 01:14:31 AM
It has no &%^emotional stuff at all so quite say.. I simply adore that blouse sweety, it looks so wonderful.....Effects? It has no &%%# bad effects and I hate how some people like to.....Feel like baking some cookie? I love to eat them hot and fresh in front of the fireplace at.....&%^$%$%$ it has no emotional effects! How could you even insinuate Progesterone causes any......Look at the cute kittens! OMG they are so adorable! They look like little fluffy balls of......So, no more comments about Progesterone causing any *^&% *^&% emotional effects becau......Oh sweetie, I am so glad your name change is official. I bet it feels so..Where am I?  ;D ;D ;D :laugh: :laugh: :laugh:

I have been researching the pros and cons of this lately till the cows come home, but after reading this....
Title: Re: Day Five on Progesterone
Post by: Wynternight on September 25, 2014, 08:09:56 PM
Quote from: Eva Marie on September 17, 2014, 01:07:06 AM
I never know what progesterone is going to do me. I've had experiences ranging from weaving in and out of traffic cussing at the top of my lungs to weeping in my office and hoping no one came by to.... no effect whatsoever. In my experience progesterone is a very weird drug, albeit with some very nice physical effects if you can get thru the emotional stuff.

I've been having that too. Today was a "wish death upon every swinging d**k on the road" kind of day once the headrush wore off. Yesterday I felt good but was easiSQUIRRELly distracted.
Title: Re: Day Five on Progesterone
Post by: TaoRaven on September 25, 2014, 08:14:36 PM
I tried it for a week. I couldn't handle the depression and drowsiness. Crying myself to sleep at 8pm is not my idea of a good time. However, it seems to have triggered quite a bit of growth in my chest area...even after I stopped taking it. 
Title: Re: Day Five on Progesterone
Post by: Rachel on September 25, 2014, 09:07:50 PM
I was taking it just before leaving for work at 4:14 AM then driving on I95 through Philadelphia. I switched to bedtime. Although I never had a negative effect I just wanted to take precautions.

I definitely am more calm and level headed but I am off all soda and caffeine for 2 months so I do not know. ( I use to drink 12 or more coffees and diet sodas a day)

I have noticed a bit of growth and conical areola. I am still small though :(
Title: Re: Day Five on Progesterone
Post by: KayXo on September 26, 2014, 09:14:24 AM
Here is my theory about progesterone...it relaxes us and that's why some of us don't like it. Let me explain. Say there is something that we carry from the past that we are sad or mad about, that madness/sadness results in bodily tension because we refuse to accept whatever it is that happened since we are mad/sad about it. If we accepted it, then there would be no sadness/madness and no tension in the body. We would totally be relaxed. So when progesterone relaxes us, it not only relaxes our body but our brain too, forcing us to let go of whatever it is that we carry from the past, ACCEPT IT, let go of the anger/sorrow which some of refuse to do so we become depressed/bitchy/aggressive, we fight back and we get scared (anxious).

I was on the fence for awhile about progesterone's effects on the rest of the body (outside the brain), whether they were beneficial or not but I really think, at this point, that it mostly does good things, like soften hair/skin, strengthen nails, give better breast growth, etc.

Other possibility is progesterone's VERY short half-life, when taken orally such that it has a positive affect on our mood for just a few hours due to its metabolite allopregnanolone and then then there is drop and we start to feel depressed/bitchy. Perhaps if levels were steadier as is the case, for example when injected (although it needs to be injected daily), then we would feel differently?

And finally, maybe, just maybe, progesterone is the PMS hormone and just makes us feel crappy. That simple. Good for breasts, for increased subcutaneous fat but otherwise, crappy. Only useful for pregnancy and nothing else. But, I don't see how nature would make womens' bodies produce a hormone for 9 months that makes them feel less than optimal. If anything, it would have to make them feel better to increase the chances of giving birth to a healthy baby...evolution, that's how things normally work.

I've taken progesterone continuously for several months, increased dose and for now, plan on keeping it.

As always, feel free to chime in and share your thoughts. And remember, we are just discussing. No intention to tell anyone what to do and all of it is pure speculation. ;)

Title: Re: Day Five on Progesterone
Post by: Jessica Merriman on September 26, 2014, 09:25:39 AM
Quote from: Newgirl Dani on September 25, 2014, 07:59:39 PM
I have been researching the pros and cons of this lately till the cows come home, but after reading this....
It was a joke sweetie!  :)

Seriously it has done wonders for me.
Title: Re: Day Five on Progesterone
Post by: Newgirl Dani on September 26, 2014, 09:24:19 PM
Quote from: Jessica Merriman on September 26, 2014, 09:25:39 AM
It was a joke sweetie!  :)

Seriously it has done wonders for me.

Yeah I know  :)  :)  :) Mine was a joke too.  Each of your sentences trailed off to nothing so thats what I did.   :)  I called my Dr's office today for an app to talk to her about this.  Because she already has many blood works, even recent, and also has me scheduled for an app in a couple of months from now I'm hoping that she may just write my script after talking on the phone.  Fingers are crossed as she knows it is a 2 hour drive for me.
Title: Re: Day Five on Progesterone
Post by: Eva on September 26, 2014, 11:23:24 PM
Quote from: KayXo on September 26, 2014, 09:14:24 AM
Here is my theory about progesterone...it relaxes us and that's why some of us don't like it. Let me explain. Say there is something that we carry from the past that we are sad or mad about, that madness/sadness results in bodily tension because we refuse to accept whatever it is that happened since we are mad/sad about it. If we accepted it, then there would be no sadness/madness and no tension in the body. We would totally be relaxed. So when progesterone relaxes us, it not only relaxes our body but our brain too, forcing us to let go of whatever it is that we carry from the past, ACCEPT IT, let go of the anger/sorrow which some of refuse to do so we become depressed/bitchy/aggressive, we fight back and we get scared (anxious).

I was on the fence for awhile about progesterone's effects on the rest of the body (outside the brain), whether they were beneficial or not but I really think, at this point, that it mostly does good things, like soften hair/skin, strengthen nails, give better breast growth, etc.

Other possibility is progesterone's VERY short half-life, when taken orally such that it has a positive affect on our mood for just a few hours due to its metabolite allopregnanolone and then then there is drop and we start to feel depressed/bitchy. Perhaps if levels were steadier as is the case, for example when injected (although it needs to be injected daily), then we would feel differently?

And finally, maybe, just maybe, progesterone is the PMS hormone and just makes us feel crappy. That simple. Good for breasts, for increased subcutaneous fat but otherwise, crappy. Only useful for pregnancy and nothing else. But, I don't see how nature would make womens' bodies produce a hormone for 9 months that makes them feel less than optimal. If anything, it would have to make them feel better to increase the chances of giving birth to a healthy baby...evolution, that's how things normally work.

I've taken progesterone continuously for several months, increased dose and for now, plan on keeping it.

As always, feel free to chime in and share your thoughts. And remember, we are just discussing. No intention to tell anyone what to do and all of it is pure speculation. ;)

Good as anyone else's... Really from what Ive gathered NOBODY knows anything definitive about it as far as MTF TS HRT goes... Even "castrated" genetic females aren't the same after that.... There must be a very delicate balance running all that and even then at their prime they still have PMS..

I liked your explanation, and I have taken P and felt SUPER calm and like OMG EVERYTHING is right and makes TOTAL sense and WOW Im SMART!!!...  Ive also taken it and felt like total crap, BAD dysphoria and lots of trouble sleeping... 

My experience has been its VERY welcome with a higher E level... When E is LOW I dont like it so much though, thats when I have trouble with it... I was cycling it but lately I think I will start the "cycle" with higher P for 10 days or so and the off "cycle with only a small dose of P... Rather than go off the P, stay on it but try cycling dosage up and down... ALL within my script for P from my DOC of course and he is fine with that BTW.... He is an OB/GYN with 30+ years experience and he cant answer most of my questions on MTF HRT, I feel like Im teaching him in a way....

Of course I will try to keep E2 high throughout with injections of EV every 5 days rather than EC every week...

Also Im talking oral bio identical P not that MPA crap... Ive taken MPA and its NOT the same at all...
Title: Re: Day Five on Progesterone
Post by: Monica Jean on March 19, 2015, 07:09:08 PM
Revisiting this topic...

Started P about a month ago.  I didn't expect much except tiredness and nothing.  Why nothing?  Everyone kept telling me that it didn't do much, even my doctor who has a good number of gender patients.

The first week or so I felt some extra tiredness, but that was it. Except for...

5 days into P, I felt the rumblings in my breasts, they have grown.  Aerolas have gotten larger, surprisingly.   I enjoy the leveling effect of P.  Didn't see this coming as I was told this makes one really moody.  It didn't for me, only leveled my moods.

I often wonder how much product is consumed by acids in the stomach and never reaches the bloodstream? 
Title: Re: Day Five on Progesterone
Post by: DanaDane on March 20, 2015, 02:30:37 PM
Quote from: Cynthia Michelle on September 25, 2014, 09:07:50 PM
I was taking it just before leaving for work at 4:14 AM then driving on I95 through Philadelphia.

I'm from Berks County.  Not that far away. 
Title: Re: Day Five on Progesterone
Post by: Rachel on March 20, 2015, 07:35:03 PM
I will be in West Reading Sunday visiting an in-law. We are very close indeed.