This is an ongoing problem for me.
This past summer, my doctor emailed me telling me to double my spiro dosage because there is too much testosterone in my blood.
I did exactly that. Mind you, when i started HRT in April, i was given spironolactone. But in August, at my last visit, she give me the pills so that it was a higher dosage, but after that i got another message from her that my testosterone is still elevated so try even higher. I've been upset to be informed of that but I'm glad she told me. Mind you my testosterone did drop to the 300 rage (if i remember correctly).
What i ended up doing is taking an even higher dosage than the last. Since i started in April I've only had one dosage of estradiol.
I'm worried that my testosterone is still up because I'm starting to have more erections and unlike the other months, I've had two orgasms in September. Is this too much?
My next visit is on October. I hope my T is down and blocked by then.
no dosages please
I'm on the same boat. Started on a low dose of cypro, three months later it was doubled and I was quite happy with the last reading (Under 30 ng/dl)... Then it started to slowly crawl up. 40, 50, 60... and freaking 70 (80 is the female range limit). Sadly, I'm on the maximum safe amount of cypro my endo will use, so...
Sometimes dosage effectivity is related to body mass. MY loss of effectivity could be well related to weight gain. SO I'm going to drop weight again and see if T goes down too..
It is not uncommon for some to not experience enough loss in T with Spiro, even on higher doses. Doctors will then switch to another anti-androgen usually.
Weight (fat) gain, if anything, would reduce androgen and increase estrogen as fatty tissue contains aromatase which converts androgen to estrogen.
Also, I read studies where high doses of Spiro and Androcur in rats were actually androgenic, probably much less than testosterone or DHT but still androgenic. These were rats though and doses quite high but still interesting...