Is it just me or the progesterone can make the voice sound boyish?? Although i get a lot of head turning and eye catching look some random hello from strangers, i feel kinda aggressive compare to estrogen and blocker only. Or maybe its just me? Whats your experience?
Progesterone can cause an increase in hunger and sex drive. Though not as potent as testosterone, it's used in pregnancy to gain the needed weight and to keep a woman interested in sex. What I was on affected me so much I needed to go on a reduced dosage.
I found no problem with progesterone.
Although my doctor would only give me a script for bioindentical progesterone which they said was the only one safe and effective. Here its expensive sadly.
But has 3 other little known medical benefits aside from breast development.
Mine is in the same vial. Progesterone plus eb. I heard that progesterone inhibit the feminizing effect of estrogen. Is it true?
You will hear a number of things said about it. At the time I was on it, the though was it would block some of the harmful effects of estrogen which would mean it would inhibit the effects of estrogen. The experts will comment soon I suspect but I think that E1- Estrone is the one you have to watch out for. The body can convert E2 Estradiol to E1 and back. E3 is pretty useless as it's on its way out of the body but it also has a blocking - protective ability.
Next week this may all be changed as that's how it seems to work out.
Quote from: Dena on June 18, 2016, 06:47:36 PM
Progesterone can cause an increase in hunger and sex drive. Though not as potent as testosterone, it's used in pregnancy to gain the needed weight and to keep a woman interested in sex. What I was on affected me so much I needed to go on a reduced dosage.
Progesterone is NOT androgenic. Pregnant women have VERY high levels and don't masculinize. I take a high dose and have noticed a reduction in body hair since taking it, along with injectable E. My T levels have also dropped. If even very slightly androgenic, it would not be prescribed to pregnant to
prevent miscarriage or pre-term abortion.
Hum Reprod. 1999 Mar;14(3):606-10."Natural progesterone is devoid of any androgenic activity that might compromise lipoprotein metabolism or induce teratogenicity."
Climacteric. 2013 Aug;16 Suppl 1:69-78."Natural progesterone and some of its derivatives, as
well as the non-ethinylated drospirenone and dienogest, do
not exert any androgenic effect and have no negative effect
on the lipids or on the endothelial cells 1,70 ."
Fertil Steril. 2002 Jun;77(6):1125-7."To determine whether the use of oral micronized progesterone (OMP) to induce withdrawal bleeding in women suspected of having polycystic ovary syndrome (PCOS) alters circulating androgen levels. »
"The mean values of TT, FT, SHBG, DHEAS, A4, and 17-OHP did not change with OMP administration."
"We conclude that the administration of OMP (* moderate dose) to induce withdrawal bleeding in women with PCOS does not significantly alter circulating androgen or 17-OHP levels, and can be used to time blood sampling in these patients."
Steroids. 2011 Jun;76(7):636-52."Prog has been reported to lack androgenic or estrogenic activity [11], [52] and [53], while possessing anti-estrogenic andanti-mineralocorticoid properties, as well as weak glucocorticoid-like properties [54],[55] and [56]. However, some of the biological activities reported in the literature are not consistent (Table 2). For example, some report that Prog has weak androgenic properties, and no glucocorticoid activity."
By weak, they mean effects only seen at supraphysiological levels.
Contraception 62 (2000) 29–38« The effects of drospirenone and progesterone on androgen-, glucocorticoid-, and mineralocorticoid-receptor–mediated induction of transcription were also evaluated using in vitro transactivation assays [10]. These assays were performed in CV-1 cells transfected with either androgen or glucocorticoid receptors and a reporter plasmid containing mouse mammary tumor promotor virus or COS 1 cells transfected with mineralocorticoid receptor and the identical viral promotor [10]. The results showed that(1) drospirenone and progesterone inhibit aldosterone-induced mineralocorticoid activity and weakly induce reporter gene transcription on their own; (2)
both progestogens have no androgenic activity but display antiandrogenic activity in terms of inhibition of androgen-receptor–mediated transcription in a dose-dependent manner [10]. »
BUT, in Table 2, progesterone is shown to have negligible anti-androgenic effect at therapeutic doses.
"this direct antiantiandrogenic effect is in addition to the more indirect antiandrogenic effect of progestogens in general, that is mainly explained by the suppression of androgen production from the adrenals or ovaries."
Journal of Investigative Dermatology
Volume 36, Issue 5, May 1961, Pages 309-319"neither in humans nor animals does progesterone produce androgenic side reactions unless given in extremely high unphysiologic doses."
About progesterone's anti-estrogenic effects:Volume 18a of Elsevier's New Comprehensive
Biochemistry, Titled 'Hormones and Their Actions, Part I', editors BA
Cooke, RJB King and HJ van der Molen. Published 1988. ISBN
0-444-80996-1. Dewey 612.405.
"Progesterone generally antagonises the actions of estrogens in various tissues."
"Depending on the physiological state, progesterone may antagonise
estrogen action. One effect of estradiol is to increase the levels of
progesterone receptors (PR). Binding of progesterone to its receptors
then leads not only to progestational effects, but also antiestrogenic
effects by causing a reduction in estrogen secretion into the systemic
circulation; by stimulating the enzyme 17B-hydroxysteroid dehydrogenase
which converts estradiol to the less active estrogen estrone; and by
lowering the levels of estrogen receptors in cells thereby decreasing
the ability of target tissue to respond to estradiol [4]."
"Progesterone also acts synergistically with estrogen in the normal
development of the breast. Estrogen stimulates cell mitosis and growth
of the ductal system, while lobular development and differentiation is
dependent on progesterone. When estrogen is administered in the absence
of progesterone, the tubular system proliferates and the ducts dilate
resultinfg in the formation of cysts and fibroses. These changes are
comparable to those observed in fibrocystic disease and are suppressed
by progestins, so that normal breast development requires that estrogen
and progesterone be administered together.[2-4]"
CLIMACTERIC 2005;8(Suppl 1):3–63
Pharmacology of estrogens and progestogens: influence of different routes of administration"In the breast of primates, progestogens may reduce the expression of the ERa and PR, but the estrogen-induced proliferation of the mammary epithelium is not inhibited, but enhanced by progestogens203."
"In contrast to the endometrium, progesterone and most synthetic progestins enhance the proliferative
effect of estrogens on breast epithelium."
"the mitosis rate in breast cancers was observed to be higher in the luteal phase than in the follicular phase325 »