Susan's Place Transgender Resources

Community Conversation => Transitioning => Hormone replacement therapy => Topic started by: Undead Cat on July 28, 2017, 12:06:09 AM

Title: solo progesterone
Post by: Undead Cat on July 28, 2017, 12:06:09 AM
I've thinking lately on progesterone, I've been taking a look at it,  and it can work as hair loss treatment and has smaller health risk side effects when compared to AAs like finesteride and SARMs, but I may be wrong ? Also it has same feminizing effects from these drugs too as I believe and I guess I'm fine with it.


Anyway , anyone already tried solo progesterone hrt and has some experience on it ?
Title: Re: solo progesterone
Post by: Kendra on July 28, 2017, 12:25:13 AM
Do you have access to an endocrinologist?  I think the best answer depends on your complete health background and measurements.
Title: Re: solo progesterone
Post by: Undead Cat on July 28, 2017, 12:28:17 AM
Yeah,  im checking my options before discussing with them the best I can.
Title: Re: solo progesterone
Post by: KayXo on July 28, 2017, 09:20:20 AM
It really won't do much alone because estrogen increases tissue responsiveness to it AND it will usually only reduce T levels to a very small extent unless you inject it and in that case, you would need to inject daily. Contrary to popular belief, progesterone has never shown to reduce DHT to a significant extent due to inhibition of conversion of T to DHT in humans at physiological levels.
Title: Re: solo progesterone
Post by: Sluggy on July 28, 2017, 12:32:43 PM
Wasn't progesterone actually effective as a male birth control in a trial, because it had so few to no feminizing affects?

It wasn't used because the people trying it didn't like the mood swings and that they also had to supplement testosterone
Title: Re: solo progesterone
Post by: AshleyP on July 28, 2017, 02:02:36 PM
Quote from: Sluggy on July 28, 2017, 12:32:43 PM
Wasn't progesterone actually effective as a male birth control in a trial, because it had so few to no feminizing affects?

It wasn't used because the people trying it didn't like the mood swings and that they also had to supplement testosterone

They use MPA to "chemically castrate" repeat sex offenders in certain states. At least they used to. I don't know if it's still in practice or not.
Title: Re: solo progesterone
Post by: Undead Cat on July 28, 2017, 02:04:48 PM
Still practiced, not sure whether or not it castrates or leave them infertile and impotent.
Title: Re: solo progesterone
Post by: Sluggy on July 28, 2017, 02:06:52 PM
Quote from: AshleyP on July 28, 2017, 02:02:36 PM
They use MPA to "chemically castrate" repeat sex offenders in certain states. At least they used to. I don't know if it's still in practice or not.
After a little research, it was Progestin as an effective/reversible birth control apparently
Title: Re: solo progesterone
Post by: Undead Cat on July 28, 2017, 02:09:28 PM
Quote from: Sluggy on July 28, 2017, 02:06:52 PM
After a little research, it was Progestin as an effective/reversible birth control apparently

Apparently it doesn't look that bad.
Title: Re: solo progesterone
Post by: Sluggy on July 28, 2017, 02:10:25 PM
Quote from: Undead Cat on July 28, 2017, 02:09:28 PM
Apparently it doesn't look that bad.
Just note that the two are very different for your body despite being similar
Title: Re: solo progesterone
Post by: Undead Cat on July 28, 2017, 02:13:58 PM
Quote from: Sluggy on July 28, 2017, 02:10:25 PM
Just note that the two are very different for your body despite being similar

Progestins and progesterone? 

Yeah, Progestins are bad right?
Title: Re: solo progesterone
Post by: Kendra on July 28, 2017, 02:22:44 PM
Reading this makes me really glad I went to an endocrinologist. 

Q: Wow Kendra what happened to you?
A: I made a typo, and...
Title: Re: solo progesterone
Post by: Devlyn on July 28, 2017, 02:27:46 PM
Last thing on my mind is reinventing the HRT wheel.
Title: Re: solo progesterone
Post by: KayXo on July 29, 2017, 01:36:05 PM
Quote from: Undead Cat on July 28, 2017, 02:13:58 PM
Progestins and progesterone? 

Yeah, Progestins are bad right?

Some progestins. Unfortunately, many endocrinologists/doctors treating us still, to this day, don't know the difference between progestins and progesterone and group them all together. Some progestins such as 17-alpha hydroxyprogesterone caproate and dydrogesterone appear to be safer. Progesterone is the hormone produced by the human body thus bio-identical and quite safe but not without potential side-effects, although usually not serious.

CPA (cyproterone acetate) is actually a progestin that's been used for decades worldwide (except in the US) in transsexual women to inhibit testosterone so it's quite ironic, to me, to sometimes read in papers that progestins don't play a significant role in breast growth/feminization in transsexual women and that it may produce undesirable side-effects when CPA, a progestin, has been so widely used in this population (was shown to increase growth of lobules and acini in breasts, in one study) and the use of bio-identical progesterone never been systematically studied in transwomen. Oh well...