Chromosomes 5,7 and Autism
http://aebrain.blogspot.com/2009/04/chromosomes-57-and-autism.html (http://aebrain.blogspot.com/2009/04/chromosomes-57-and-autism.html)
5/29/09
From Genome Web :
The first common variant associated with autism has been identified and validated, according to a new study scheduled to appear online today in Nature. The paper, one of several autism genetic studies published online this week, supports the idea that autism involves altered connections between neurons or brain cells.
A team of researchers from across the US genotyped more than 10,000 individuals in an attempt to uncover genetic variants and copy number changes linked to autism and autism spectrum disorders. Their search turned up half a dozen common SNPs in a region on chromosome 5 between CDH9 and CDH10, cadherin genes coding for proteins that help glue cells together. One of these reached genome-wide significance and appears to account for roughly 15 percent of the population risk of autism.