Susan's Place Transgender Resources

Community Conversation => Transitioning => Hormone replacement therapy => Topic started by: Nicole Meadows on April 26, 2010, 01:55:55 PM

Title: HRT hypersensitivity? . oral estradiol still too much...
Post by: Nicole Meadows on April 26, 2010, 01:55:55 PM
Hi everyone. First post here. I'd like to start by asking a question about hypersensitivity to HRT. I'm sensitive to most drugs in general and am having an especially difficult time adjusting to HRT, even in meager amounts.

About 18 months ago I began a prescribed regimen of  oral estradiol. I only lasted four days before having to stop. It was too intense, as if I were having an out-of-body experience with uncontrollable runaway thoughts. I also experienced waking up in the middle of the night with a rapid heartbeat and feeling needle pinprick sensations through my arms and fingertips that lasted for days. Something was wrong. However, with the bad comes the good, and I also experienced positive changes in color perception, emotional sensitivity, sexual response, temperature sensitivity, enhanced sense of smell, and other changes similar to those reported here.

It amazes me how people who take 3x-4x of what I did report they "don't feel it very much". I wish that were the case with me! I can take as little as .once, and within 20 minutes it PROFOUNDLY impacts my perception and behavior for DAYS. Seriously.

I'm planning to visit a different therapist and see if my experience can be corroborated with others. So far, nobody has any idea of why this is happening, but I've heard lots of comments such as: "Are you sure it wasn't LSD?", "Are you sure you aren't imagining this?", "Has to be psychosomatic", etc etc. I'd be laughing too if my future happiness wasn't, like, so totally on the line here. Grrr.

Since reducing the dosage didn't help, at this point the only thing I can try is changing the *type* of estrogen as well as the *route*. Maybe go with a patch next time? Ugh. I'm so bummed out over this!!!

~N

P.S. I can't seem to add my photo to my profile. Do we have a make-10-posts-first kind of restriction in place? Thanks. :)
Title: Re: HRT hypersensitivity? .25mg oral estradiol still too much...
Post by: LordKAT on April 26, 2010, 01:58:05 PM
No posting of dosages. You may want to change that.

15 post restriction


too many e receptors?  no idea on that part


BTW, welcome to Susan's
Title: Re: HRT hypersensitivity? .25mg oral estradiol still too much...
Post by: cynthialee on April 26, 2010, 02:01:37 PM
Talk to your prescribing doctor. Hormones are very powerful chemicals that effect more than is visable.
Title: Re: HRT hypersensitivity? . oral estradiol still too much...
Post by: Janet_Girl on April 26, 2010, 02:06:28 PM
I was going to say the samething.  See your doctor.
Title: Re: HRT hypersensitivity? . oral estradiol still too much...
Post by: Jasmine.m on April 26, 2010, 02:28:06 PM
Quote from: Nicole Meadows on April 26, 2010, 01:55:55 PM
feeling needle pinprick sensations through my arms and fingertips that lasted for days.

The term for this sensation is paresthesia. This, along with the others you mention, are common adverse effects seen with oral estradiol. You should talk with a doctor about them.
Title: Re: HRT hypersensitivity? . oral estradiol still too much...
Post by: andream on April 26, 2010, 08:58:09 PM
I experienced that itching sensation when I was on high dose spironolactone a day. My left arm would itch like crazy, and it would keep me up at night. I stopped spiro, and started using androcur instead, and the itching went away.


No Dosages please