Hi,
A little different for myself , my own hormones started changing about 21 years ago .  in prep for becoming a woman so what little the added hormones have done is just what is normal for a menopausle woman  for health reasons, so HRT = E.  was about 10 years ago  .
 as for Spiro my body rejected them , so was not on them long ,
as some of us  are different the synthic meds dont allways work for every one , 
...noeleena...