Quote from: KayXo on April 27, 2018, 09:28:48 AM
Has this been actually shown in studies?
If you're comfortable reading scientific papers, I'd suggest looking art this one:
https://www.ncbi.nlm.nih.gov/pubmed/23914154Role of hormones and neurosteroids in epileptogenesis.The paper is open access, so if you follow the links to the journal website, you can download a full copy of the paper free of charge. Although it's specifically about their role in preventing epilepsy, it has lots of useful information about how neurosteroids are produced, and how progesterone acts as a raw material from which allopregnanolone, one of the key neurosteroids, is made. It also mentions how progesterone can be used as an anti-epilepsy treatment in people who are deficient in it, and how finasteride depletes neurosteroids and raises the risk of epilepsy by blocking 5 alpha reductase, one of the enzymes involved in producing allopregnanolone and other neurosteroids.
Although it doesn't talk about progestins as a cause of neurosteroid depletion, unlike progesterone they don't undergo conversion to allopregnanolone (so are no substitute for progesterone in that regard). Furthermore, I know from what I've read elsewhere that many progestins are quite strong inhibitors of 5 alpha reductase, so probably block neurosteroid production by that route in a similar way to finasteride.
Neurosteroids don't just prevent epilepsy, they drive neurogenesis (the creation of new brain cells), and appear to be crucial in maintaining a healthy brain and nervous system.
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Increased mortality or incidences without mortality? Not the same. If mortality, was the increase statistically significant and how much was the absolute increase?
I think in the published results from the WHI study showed roughly a doubling in all causes mortality. Whatever they found, it was bad enough that they cut the study short, and doctors no longer routinely offer postmenopausal HRT because of it.
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Wouldn't this require frequent injections, at the very least every 2-3 days and be impractical? By 24 hours, a study showed levels already significantly dropped in most and in pregnant women, injections are done daily to keep levels steady.
Yes, it has a short biological half life and you'd probably have to inject it every other day to maintain steady levels. Unless you're doing subq injections, it probably wouldn't be practical. I'm just going on what I've seen other people saying that you can inject it, I use the cream so don't have personal experience of the injected form.