I'm curious,  since I have been on Estradiol in March I have had trouble sleeping through the night. I used to sleep until about 7 a.m. or 8 a.m every morning  even some mornings until later.  I never paid no mind to it until recently,  but I seem to be waking up about 4:30 to 5:00 am. now every morning.  Sometimes even earlier. I am having a hard time staying asleep I just can't figure this out. I never had this issue before. I guess it is a plus because I go to bed at 9:00 p.m. every night and I guess getting 8 hours sleep  is good, but I'm  not really getting a solid 8 hours. Sometimes I'm  up at 3:00 a.m. or so and this varies.  I find it very easy to initially fall asleep, but when I wake later it is hard to stay asleep.  Has anyone experienced this when they started hrt?