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HRT Oral Medication - The Long Term Health Effects

Started by VictoriasSecret, January 14, 2026, 03:38:51 PM

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VictoriasSecret

Hello All,

A little bit of health awareness on the long term effects of HRT oral medication.

Apologies if this topic has been addressed already.

Several years ago, my doctor changed my oral hormone medication to a gel topical application.

The reason being is that I have been on varying hormones over the years from tablets to injections and now the topical gel but the Dr was concerned of the long term effects of these medications going through my kidneys and liver.

As the bulk of these medications have done their job, it was just a matter of now maintaining levels without putting any undue stress on said organs.

This puts my mind at rest with the doctor showing care and attention to what is happening with my body as I age (I turn 60 in December!!!)

I started hormones from the tender age of 18, making this year my 42nd year of HRT!!!

No doubt, once my surgery is complete in August, my needs for hormones should drop in dosage.

Can anyone else who has been though this process and come out the other side, shed some light on post surgery HRT and changes in medications?

Blessed Be

Victoria.

May the Goddess light your way with calm and clarity.
Blessed Be
Victoria
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NancyDrew1930

I haven't gone through the surgery but last year when I was talking to the clinic I'm with, I was asking if with gastric bypass surgery I would have any issues after with the pills when taking them sublingually, and the doctor didn't think so of if I stayed on the sublingual (under the tongue) method, since that bypasses the liver and puts the estrogen directly into my blood stream, so it doesn't get processed by the liver. 

Allie Jayne

There is a lot of literature available about the increased risks of long term oral estradiol, and most doctors would recommend switching to transdermal therapies, but your post seems to be more about post surgery HRT strategies?

I am a believer of using minimum medications, and post my surgery 5 years ago, my doctor and I have been slowly lowering my dosage. I am in my 70's, but our plan is not to go to post menopausal levels many doctors aim for, and this is because I do experience menopausal symptoms if my levels fall too low. The standards many doctors rely on are for cis women, and most are based on an outdated report ( the Women's Health Initiative) which is written around older synthetic hormones which have greater health risks than modern bio identical hormones.

So, we need to let our doctors know our expectations, like feeling healthy and not suffering menopause symptoms, and develop a hormone plan to achieve this. My doctor has switched me to inserted pellets as they provide the most even delivery, and best of all, only need to be inserted around once per year. My care is more based around how I am feeling rather than arbitrary levels prescribed for 'average' cis women.

Best wishes for your surgery and recovery! My surgeon made me cease hormones for my perioperative period, and I had severe menopausal symptoms in hospital including headaches and night sweats, which complicated my post surgery care as it can also indicate infection (which didn't happen). Current advice is to not cease hormone treatment in the perioperative period so you have the best post surgery recovery. Also, hormone interruption has been linked to post op depression. Make sure you discuss this with your surgeon well before your surgery date. My surgeon in Melbourne changed his policy on this after my surgery as I gave him the papers with current recommendations.

Hugs,

Allie

VictoriasSecret

This is sound advice @Allie Jayne.

Thank you for sharing.

No doubt you will see of my story unfold as time goes on.

Blessed Be

Victoria. xx
May the Goddess light your way with calm and clarity.
Blessed Be
Victoria
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    The following users thanked this post: Sarah B, Lori Dee