I'm just a bit too old to remember the 2000's high school shows I guess, I was 24 by the year 2000. But I love the creativity you are showing. Is your target audience kids or teenagers or is it adult humour?
Cool US animations for me growing up were things like Ren & Stimpy or Beavis and Butthead I suppose. I quite liked pinky and the brain as well actually!
A lot of the childrens tv back when i was young was homegrown UK stuff that just isn't really repoduced anymore, it all seems to be imported things. UK stuff was very gentle, quiet and sweet, think Bagpuss, Fraggle Rock, Trumpton and the like. That said we had some amazing animated series like The Mysterious Cities of Gold, Battle of the Planets (G-Force I think you guys called it) and Ulyses 31 which were all japanese/french creations.
Good luck in your venture, has it been commssioned or are you looking to pick up a buyer?