I used to live in a really bad place in California (trust me, not all of Cali is as pleasant and accepting as everyone seems to think). I got into my fair share of action there.
Once a guy started talking dirty to me on a streetcorner where I was panhandling (I was homeless at the time) and grabbed my breasts. He knew I was trans, since I had dealt with him once before in the past....and up close I wasn't 100% passable(though from more than a few feet, nobody could tell). He was probably a good 210 pounds, and I about 120 pounds, so he probably assumed he had the upper hand and that I wouldn't try anything. I hit him square on the temple and smashed his expensive looking glasses which seemed to really get him angry. Anyway, he started punching back, and we spent about eight minutes thrashing each other good while cars at the intersection cheered me on (nobody came to help, but they all thought it was great fun to watch a little girl fending off a man twice her size) At one point the fight got to the ground and I shoved my long thumbnail into his eye, which got him off of me. He went for a big chunk of broken sidewalk coming at me with it, but I evaded him with footwork, so he tried to shot-put it at my head, but missed me by about a yard....I'm guessing his depth perception was off. (his eye was bleeding pretty badly).
At that point the wail of sirens was drawing near, and he took off running. I was in no shape to run, nor did I have reason to. The cops never caught the guy, and I didn't pursue pressing charges. I walked away from it with some scrapes, a bunch of bruises, a broken rib, and some hair pulled out of my head, and feeling pretty lucky. I was sore for the next two weeks.
There were some other instances where some people tried to start a fight, but those times didn't amount to much. Although, once, in a bad part of the same town a guy I didn't know came at me asking how much it cost for sexual favors. I said something to the effect of "If you're going to approach me, you'd better come with respect,and I don't play those games" when all of the sudden from out of nowhere this drug dealer I knew just came up and clocked him right in the face and broke his nose. It was pretty cool.
Just goes to show, even in the worst of places, there's always some good