I'm not sure that ancient eunuchs were all that frustrated because a big source of their sex drive was taken out of the picture. Not saying that they don't have a drive but in general. Whatever the term meant, and going back to the original greek, the idea is somewhat the same.
God loves all people, cis people, people that have altered themselves, people that are intersex etc. As to what the transgender community looked like in the mediterranean at the time the bible was written is anyone's guess as there is very little data on it, but i think we can certain it existed in some form and God loved them, as he does today.
As to the bigoted special interest groups and people that draft language at conventions and such, nothing is that new there. They like all regressives are desperate for a "culture war win" and are doing as much work as they can to influence the people that they have in churches to agree with them.