I urge anyone who wants more information on progesterone, T blockers, estradiol, estrone, etc., and how they all work for trans folks to look up "Dr Will Powers" on Facebook, download his latest PowerPoint presentation on Care of the Transgender Patient, Version 5, and study it end to end. Seriously, this guy is extremely dedicated to us, reads the published studies, does his own research, and is loved by all his over-1200 trans patients. He has people flying to see him from as far away as California. I almost wish I lived in Michigan again so he could be my primary doctor.
I've already given my PCP version 4.0 of his presentation, and I intend to distill his latest findings on progesterone, along with the knowledge I've gained from this thread, and present it at my next appointment as proof that I should be on progesterone.
In a nutshell, he now refuses to use T-blockers, especially spiro, any more, since he's found that proper dosages of estradiol, administered appropriately for each individual, along with bioidentical micronized progesterone taken as a suppository, suppress testosterone adequately. He also recommends progesterone in cream form applied to the breasts and even the face. I won't give any more details here, but I strongly suggest you take a look.
Stephanie