Point Nemo is located in the South Pacific Ocean roughly 2,688 kilometers (1,670 miles) from the nearest landmasses (Ducie Island, Motu Nui, and Maher Island), it is the most remote spot on Earth.
When the ISS orbits at an altitude of approximately 400 kilometers, the astronauts inside are significantly nearer to this oceanic void than anyone on the distant, uninhabited shores surrounding it.