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Male losing their Y gene as they age, may be related to Trans people?

Started by Allie Jayne, February 16, 2026, 07:19:50 PM

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Allie Jayne

It has been known for a while that Males can lose their Y gene as they age, but until recently, the Y gene was thought to have little effect. Recent studies have linked the loss of the Y gene to many health conditions.

https://theconversation.com/men-lose-their-y-chromosome-as-they-age-scientists-thought-it-didnt-matter-but-now-were-learning-more-275823 🔗

Though it has yet to be studied, this may have implications for trans people. Increasing trans awareness and dysphoria in older males has been known forever, and was erroneously dubbed 'late onset transgender', but maybe the loss of the Y gene could explain why many people do not discover they are trans until later in life! I believe we are born trans, but many don't have an awareness until later in life.

In my own case, from middle age, my Testosterone level fell significantly, and my dysphoria levels raised significantly, eventually affecting my health. It could be that the trigger for this to happen was the loss of the Y gene. We won't know until research is done, and I would imagine there are no plans for this in the foreseeable future, but it might one day add to our knowledge.

Hugs,

Allie

BrianaJ

Interesting article. I'm glad she included the sentence regarding association does not always mean causation.  I think many times people have a difficult time with that concept.  It also doesn't seem like it's something one would want given the possible negative health implications.

I also didn't find any mention or relation to trans people.  Did I miss a paragraph/page ??
~~Be kind~~
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