I got into a conversation once with someone who is a lesbian, but didn't understand transgendered issues in terms of religion. She told me she didn't understand it because she felt that God made us perfect the way we are. I gave her my point of view, which was this.
God doesn't make perfect in terms of how WE see things. We are human, therefore, we are imperfect by nature. What He does is set people on a journey, which is called life. The people who are transgendered, that is part of THEIR/OUR journey. That doesn't make them/us imperfect, it's part of the struggle of being human. It's how we handle that struggle, how we survive and make an impact, that's what the point is. The Bible was written by men, how can we know exactly what God thinks? So He makes people differently because everybody has a different walk of life, and what you encounter in that life is what makes you closer to God in understanding how He sees things. The people you encounter add to this. My life is enriched by meeting people who are different from me, because I learn more about the world we live in and more about different lives.
I am a Christian by faith, but most Christians are ignorant and shameful. God does not want us to conform to His standards. He wants us to live our lives with integrity, honesty, and to do no harm to other human beings. That's basically it. What's wrong with that?