Norethindrone acetate

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Norethindrone acetate
Systematic (IUPAC) name
(17α)-17-ethynyl-3-oxoestr-4-en-17-yl acetate
CAS number 38673-38-0
ATC code  ?
PubChem CID 63021
Chemical data
Formula C22H28O3 
Mol. mass 340.456 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral

Norethisterone acetate or norethindrone acetate is a progestin used in contraception. It is the acetate ester of norethisterone.

Norethisterone (or norethindrone) (or 19-nor-17α-ethynyltestosterone) is a molecule used in some combined oral contraceptive pills and in some progestogen only pills. It is a progestogen and can be used to treat premenstrual syndrome, painful periods, abnormal heavy bleeding, irregular periods, menopausal syndrome (in combination with oestrogen), or to postpone a period. Norethindrone was the first orally highly active progestin to be synthesized. It was synthesized for the first time by chemists Luis Miramontes, Carl Djerassi, and George Rosenkranz at Syntex in Mexico City in 1951. It was the progestin used in one of the first two oral contraceptives. It is often used as the related ester, norethisterone acetate.


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