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Phytoandrogens are substances produced in plants which have effects similar to testosterone in animals. Daidzein, an isoflavone found in soy and elsewhere, has been described as a phytoandrogen.[1] Triterpenoids from the gutta percha tree can act as phytoandrogens.[2]

As HRT for trans men

Generally speaking phytoandrogens work by weakly binding with the androgen receptors. In some cases there may be very mild virilization. However, the doses required to major effects are so large and toxic that there is a real risk to health. Most sources do not recommend that trans men use products such as Diosterol, Gamma Oryzanol, Mesobolin, Smilax Officinalis, or any other phytoandrogenic herb as a replacement for hormone therapy, even as a low-dose measure, because of their inefficacy.

Some trans men have reported benefits to use of Dehydroepiandrosterone (DHEA). More studies are needed to ascertain the effectiveness and safety.


  1. Chen JJ, Chang HC (April 2007). "By modulating androgen receptor coactivators, daidzein may act as a phytoandrogen". The Prostate 67 (5): 457–62. doi:10.1002/pros.20470. PMID 17252558.
  2. Ong VY, Tan BK (2007). "Novel phytoandrogens and lipidic augmenters from Eucommia ulmoides". BMC Complementary and Alternative Medicine 7: 3. doi:10.1186/1472-6882-7-3. PMID 17261169.


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