Oh, my metabolism is a lightning bolt. Took four months to gain 25 pounds when I was eating 4000 to 5000 calories a day (every day). If I eat 2500 calories a day, I actually lose weight. But still my doc has me on some pretty low doses compared to what I've heard from others. Like you, Ann, I have to take mega doses of everything. And because I also have a superhero liver, my body flushes out and and compensates for anything I take with utmost efficiency. I've literally had the strongest dosage of the strongest medication stop working in four days. Baffled my gastro doc to no end.
Yes, my HRT doc is extremely conservative in her approach, but I don't think conservative will work in my case. She's also not willing to get experimental. She told me that if her two regimens don't work (spiro/low-dose E or depo/low-dose E) then I'm one of the unlucky ones who can't expect benefits from HRT.
It's maddening because I'm just not seeing any of the changes everyone else talks about.