I'm working my way into the entertainment industry (as a concept artist and 3d modeler) and it seems to be pretty friendly so far.
From what I hear, artists in general in the industry can be kind of strange... but as long as you are fun to be around, it doesn't matter.
Actually, if anything, my differing presentation has actually helped. It seems to make people curious about me and trust me more as an "artist" ... because... I guess I look the part. I would say it definitely pays to stand out a little bit (as long as it is standing out in a good way).
Other creative types seem to really enjoy that I am trans... they find it interesting (something creative types always love). ((Also, people have been extra understanding at these starting stages when trans stuff seems to get in the way of getting things done... but, of course, that won't fly for long

)).
As my character sculpting teacher would say, "all people are freaks, take time to really look at people around you and see just how different we all are". He LOVES different types of people... it is his job to study and learn about all types of people

Basically, I feel pretty comfortable transitioning in this place and this industry. People look at me curiously now and then... but, it really doesn't seem like negative looks... it seems like a look which is saying "hmm, that is interesting... I like what I am seeing".