I went full time in '06, lost some friends right off the bat, others have dropped over time, still have some though. My family is overall supportive, although it took a year or two for one of my brothers to come around. My dad was fine with it, even helped me with some of the endo costs and wanted to pay for my surgery, but he was ill with cancer and I couldn't take his money when I'd rather him have used it to make what time he had left as good as was possible.
I've had some harrassment, but most has been resolved satisfactorily. I have a job, not a great one, but its close to home and the customers are nice for the most part, coworkers are great. I rarely worry about my safety and a few people that live around the store do kind of watch out for me when I am there alone at night. I'm still wary of making friends though, been through enough with that crap that I'm not sure its worth the bother anymore. I don't date even though I have been asked out, that's mostly because I prefer to not get into any sort of relationship while I am still pre-op.
Overall, I like my life, its not perfect, but I see other people with way more messed up lives than I've ever had, so I'm thankful for what I do have in mine.
Everyone's experiences are going to vary and they will all have different tolerance levels for what they will put up with from family and friends, my tolerance level is not terribly forgiving unless I know someone is genuinely trying.
The main thing is to do what's right for you, its your life, not theirs. That's not to say that you have to totally selfish, because you don't, but transitioning doesn't have to be as selfish as so many non trans people seem to think it is.