I am on the estrogen patch and spiro. I was hoping for some changes in the skin , and with the mind, and some reduction in the fat gut that I have, such as a redistribution of the fat. A change in the thickness of my hair would have been nice. Besides some breast growth, I am more sensitive to electrolysis (its too painful). No noticable changes anywhere else. So if the estrgen isn't going to do anything for me then why take it. Oh, and I do cry more while watching a movie.