It is going to depend on where you are in the TG spectrum. Around three months on estradiol, depending on the dose, expect breasts to start becoming tender. They will continue to develop, (gynecomastia) not female breasts (depending on where you are in the spectrum) over the next 3 years. Usually MTFs will not get bigger than an small B. THere are exceptions. Skin will become thinner, muscle mass will start to decrease from 4 - 6 months, blood will become thinner, and if you test as a male after approx 6 months you may possibly show up as anemic, Liver will decrease production of ADH (alcohol dehydrogenase), so you will find that you get drunk easier, and your blood alcohol level will be higher after one drink. Watch out for DUI. Voice will NOT change, it is physically fixed, (does dramatically change for FTMs on T). These are just a few changes as well as mood swings and crying jags.
Hope this helps.
Nathine