The best way is to try not to think or obsess about where you are versus where you would like to be too much. Since I have ADD and a weird personality, this isn't too hard for me: my mind skips over things to think about constantly, without me wanting it to, and not getting too down about things because I forget them often is one of the very few advantages of this abnormal behaviour. But even normal people can do that. Keep your head busy with other things.
Also, in some people, estradiol can cause depression, temporarily or not, as a side effect. It's a possibility. If you're in the unlucky boat of those who need estradiol for happiness yet it gives you an "artificial" depression, and it's permanent (the chances are probably low if it's any consolation), perhaps your only solution would be to take both estradiol and depression medication. But before you get to that point, make sure, with a therapist if needed, it truly is a medication side-effect, and that it truly won't be going away.