I'm originally from Oklahoma and my entire family consists of die-hard Christians and Republicans.
I came out on Facebook.
This happened a few months after I graduated high-school, and I actually made a point beforehand to delete anyone on my friends list that I didn't regularly talk to. I doubt that anyone would have been rude about it, but I didn't necessarily care to tell them because I don't anticipate ever speaking to any of them again. The leftover friends were close ones in real life and from online, and also family. I didn't have a single friend who wasn't supportive. My family, however, had some offensive things to say online.
All in all, it made my mom look like a really crappy person. I love her to death and I know she loves me, but she took it really hard. We talked about it on the phone and she was fine, then she went online and scolded me and any friends that tried to defend me. She posted something the other day and tagged me as her daughter, so while I thought we were done with this, it's clearly still an issue to be discussed. But, I digress...
Overall, I'm satisfied with having come out online. It's a little unnerving to not be sure whether someone has seen it or not, but the news made it around my family pretty quickly. Everyone knew within a couple of weeks.
I don't live with my family, and don't communicate with them that often. I think that it's been harder to get them to accept this because of that, in that they don't see me often enough for me to make an issue out of improper pronouns or whatever. I'm on T and they all know it, but as far as I can tell... they're just ignoring it.
In respect to my own family, through coming out on Facebook, it hasn't been an issue discussed much in person. Most of my extended family knows, and I know that they know, but we don't talk about it. They haven't mentioned it in more than a comment or two online, and that's how I like it personally. I don't particularly care what they think as long as they're not harassing me, and even if they were supportive, I'd probably be uncomfortable discussing it with them face-to-face. It's just not an issue I really want to talk about, if I don't have to.