GYLF,
I am a little slow on the reply here, but I will offer my experience. I live in a relatively small place, so no space for a sewing room or any large tables to spread everything out. I do have a queen size bed and use it for setting out what project I might be working on. I use an OLFA cutting mat size 23" x 30" for cutting out fabrics. To get a good cut I often have to put in on the floor (I do have hardwood floors), but have used it on my bed with a folding table on top. I machine sew/quilt large items using a small folding table and I definitely do not have a large machine, which I have to store both it and the table under my bed. I try to spread all the material out as much as I can, focus on a very small sections at a time, and go very slow. I also use a walking foot on large projects regardless of thickness because it keeps the fabric from sliding around when there is so much. It also helps with pulling the fabric through when the weight on either end might be too much. I use disappearing ink pens a lot and draw lines on the fabric to keep me guided, which without it is easily to lose your spot or alignment.