Quote from: JoanneB on March 22, 2013, 05:13:06 AM
The uptake of many meds is affected by, of all things, grapefruit juice. Occassionally there wll be a warning telling you not to drink or eat grapefruit if you are taking XYZ. You'll get a lot more bang for the buck. I read an article or two on how it interferes with the liver enzymes some keeping it from eating up the chemical allowing the rest of your body to see more of it.
This includes estrogen. Everyone here is prob taking a sublingual version of E, or should be, but it still undergoes metabolization by the liver enzyme CYP450. It's very powerful liver enzyme and grapefruit juice is known, for a fact, to inhibit it. There are meds, like tagamet, which also inhibit it and will make your E levels dangerously high. On the flip side, don't take St. John's Wort either as it induces that same enzyme and will flush the E from your system. The effect is not negligible either.
As far as spiro, I just found out by accident because I don't eat much but when I ate yesterday and then took the spiro, I got really tired. More so then usual. I do not think food will effect orally-taken E, but if you are taking estrofem, you really should be taking it sublingually as both clotting risks and negative liver effects diminish.
