I just read that taking your spiro dose with food increases its bioavailabilty by 100 percent compared to taking it an empty stomach. it still works on an empty stomach but by taking it with food, it's almost like taking double the dose if you usually take it in the morning and don't eat breakfast. Just thought I'd let you all know. It's a pretty big difference.

Good to know!  I'm going to take mine with breakfast tomorrow!

Does that include chocolate? 

Is there any information on the E with food vs no food? When I take mine after my shower, I feel like my body thinks its breakfast and it just goes right through me.

The instructions with my E tablets say it does not matter if you take them with or without food. It does mention alcohol as something that impairs them though.

The uptake of many meds is affected by, of all things, grapefruit juice. Occassionally there wll be a warning telling you not to drink or eat grapefruit if you are taking XYZ. You'll get a lot more bang for the buck. I read an article or two on how it interferes with the liver enzymes some keeping it from eating up the chemical allowing the rest of your body to see more of it.

So I guess I'm golden then since I always take my meds just after breakfast!

Quote from: JoanneB on March 22, 2013, 05:13:06 AM
The uptake of many meds is affected by, of all things, grapefruit juice. Occassionally there wll be a warning telling you not to drink or eat grapefruit if you are taking XYZ. You'll get a lot more bang for the buck. I read an article or two on how it interferes with the liver enzymes some keeping it from eating up the chemical allowing the rest of your body to see more of it.

This includes estrogen. Everyone here is prob taking a sublingual version of E, or should be, but it still undergoes metabolization by the liver enzyme CYP450. It's very powerful liver enzyme and grapefruit juice is known, for a fact, to inhibit it. There are meds, like tagamet, which also inhibit it and will make your E levels dangerously high. On the flip side, don't take St. John's Wort either as it induces that same enzyme and will flush the E from your system. The effect is not negligible either.

As far as spiro, I just found out by accident because I don't eat much but when I ate yesterday and then took the spiro, I got really tired. More so then usual. I do not think food will effect orally-taken E, but if you are taking estrofem, you really should be taking it sublingually as both clotting risks and negative liver effects diminish.

Interesting. I take mine in the morning around 6am, and I don't eat breakfast. Good to know.

good to know