Think about depression. Most people feel down at least part of the time, but they get back to feeling normal before long.
Full blown depression, though, can make everything feel gray. You may still be able to function, but you don't feel normal. The feeling follows you all over.
Being trans is similar. The feeling of being out of joint follows you. That can cause lots of stress. Maybe you don't get depression or severe anxiety from it (although these are common things that come with the territory), but the feeling is a finger constantly pressing down on your head.
Now, a doctor may see things differently, but I would imagine that if that pressure made you want to seek help, that would qualify as significant.
At least, this was the conclusion I reached in the end when I read the diagnostic criteria.
Does that mean a doctor will conclude you are trans? No, it doesn't. But please don't let the word significant stop you from getting help. You need help when you need it.