Anyone Ever Take Estrogen Both Orally And Sublingually?

[Andarta]

I'm curious if anyone has ever attempted this or was instructed by a doctor to do so, the curiosity springs from reading others talking about benefits from oral administration that seem to not be present during sublingual administration an vise versa. For instance i've read that the lower forms of estrogen that estradiol  is converted into from oral administration has some benefits with development this makes me wonder if a combo approach an all forms of estrogen being present would have some benefits. Thoughts?

[Jessica Merriman]

I am on the Estradiol patch. I like this best because it goes into the blood stream without passing through the liver. It is also one of the safer forms for someone of my age (47). It decreases the chances of Deep Vein Thrombosis, Stroke, cardiac issues and a few other things. The only downside I have is sometimes it wants to come off easy and every once in a while it irritates the skin. You need to go a week with it in a different place and then move it back after that. I take Spironolactone orally, but no Estrogen. As a retired paramedic I feel that the sublingual route is the best, but listen to your doctor for all meds and routes. Hope this helps some. Have a great day today.

[sam79]

A little while back I tried both with cycled two week periods ( two weeks under my tongue, two weeks swallowing ) to see if there was any difference. Can't say I noticed anything. Now I just swallow the little blue pills because it's easier.

[Ltl89]

I'm curious if anyone has ever attempted this or was instructed by a doctor to do so, the curiosity springs from reading others talking about benefits from oral administration that seem to not be present during sublingual administration an vise versa. For instance i've read that the lower forms of estrogen that estradiol  is converted into from oral administration has some benefits with development this makes me wonder if a combo approach an all forms of estrogen being present would have some benefits. Thoughts?

I only go the sublingual route.  What benefits are there from oral administration as opposed to sublingual?  I'm curious if I'm missing out on something. 

[sam79]

One theory you may find around is that it bypasses the liver, which is a myth. Estradiol still has to be converted by the liver. The second thing people say is that it can be more effective using sublingual administration; if done correctly. But apparently this results in a faster 'hit', but shorter duration of the drug in your system. Taking it orally is supposed to be more consistent from dose to dose, and supposed to release it over a long time period.

[Ltl89]

One theory you may find around is that it bypasses the liver, which is a myth. Estradiol still has to be converted by the liver. The second thing people say is that it can be more effective using sublingual administration; if done correctly. But apparently this results in a faster 'hit', but shorter duration of the drug in your system. Taking it orally is supposed to be more consistent from dose to dose, and supposed to release it over a long time period.

Interesting.  I'm supposed to see my endo next week, if my insurance company gets its act together.  I'll ask her whether there are any benefits or not.  To be honest, I would just assume that both methods get you to the same place.  I only take it sblingually for the benefit of saving my liver  which has gone through some battles during my 24 years on this Earth. 

[jamielikesyou]

My former doctor suggested micronized estradiol sublingually to avoid first pass effect. My current physician suggested to just swallow them whole as sublingual administration creates larger variance in serum estrogen levels (as Sammy stated.) She feels swallowed tablets provide a more consistent and predictable dosing. This is based on my risk factors which, outside my age (42) are minimal, (excellent liver function tests, non drinker, non smoker, consistent weight loss, etc.) She said not to worry about first pass, let the liver do its job.

This is my experience only, so please ask your physician about it as they will be able to apply current research to your medical profile.