This is really interesting to me, because I was also concerned about time of day for dosing. When I asked my endocrinologist about what time of the day would be the best, or whether or not I should split up the dose, he said "it's more of a buildup sort of thing" and that dosing time is pretty much irrelevant. On the other hand, on the Estrofem box, it says pretty clearly that it's best to take them at the same time every day, so what's the deal?