I have wine or alcohol a few times a week and have been on HRT for the past few years. Other than not having full hips and less body hair in a few places, I'm not convinced alcohol has hindered me at all. Now would I shoot my doses with any booze? Hell no! In fact, I have a window of a few hours of not drinking after I've taken my dose. I don't want to tax my liver more than it needs to be. I do get my full gamut of bloodwork done yearly, if not semi-yearly.