I just want to chime in a little my my personal experience with Cyproterone. I take Cyproterone (even though it's not officially available in my country, long story...) once a day at the lowest dose you can take (without splitting pills). Two months after starting it, my testosterone levels were within the normal female range, and they have stayed there ever since. Cyproterone is one of those drugs that people can respond to very differently. For some you can get away with a low dose and have great results, but for others you may need a high dose (that comes with a serious risk of complications) to accomplish basically the same thing. I think your endocrinologist was right to start you with a low dose, because if it is effective then you should get great results without having to worry too much about things like liver damage. If your testosterone levels are still above the normal female range in two months, and your doctor refuses to increase the dose, then you might want to consider trying to find another doctor. But even then, keep in mind that Cyproterone is actually know to increase effectiveness over time (due to testicular atrophy), and the estrogen you take should also act as an anti-androgen. And taking a higher dose of Cyproterone may interfere with feminization since Cyproterone is a form of progesterone, a hormone that competes with estrogen.