We're all human, and hormones determine the sex of a person in the womb and appearance during puberty. With that being said, hormones effect us all the same whether you're transgender or cisgender. The risks are the same as a biological man, so naturally: higher blood pressure, cholesterol, slight more risk of cancer, heart disease, and liver complications. Plus, shortening your life span to the average male. The only negative effect that can happen, that's different for trans or cis males, is the risk of ovarian cancer. It's recommended that you get a hysterectomy. The sooner the better, but personally, I'm waiting since I want to find a way to store my "sperm"..