The adhesive on the patch is actually the estrogen delivery method, but the thing is, it doesn't have to be *sticky* to continue to deliver E. I checked with my endo and pharmacist, and both said if it falls off that's a problem, but a bit of sweat underneath it won't interfere. Manufacturers build a little tolerance into the patches because they know it's impossible for them to work perfectly on humans outside of a lab, too. So the amount provided is *relatively* stable, but there's going to be a teeny bit of variation over the course of a day as we move, sit, etc. I second the recommendation for an alcohol cleaning of the site beforehand, and I had some luck with surgical tape when I was using Climara (haven't needed it on Vivelle).
Jessica : That's basically true, but the patches only need to provide a tiny amount of E per hour, so losing a little to sweat (a very, very little, the pharmacist says) is not a problem. It's the same thing that happens when the patch loses contact due to skin wrinkling, and is within tolerances.