I had headache problems for about a week after surgery, and I was back on my estrogen the morning after my surgery. We did narrow mine down to basically an anesthetic hangover from the time I was under, along with the morphine I had during the first night. I had not been off my E since I normally take half of what my surgeon recommended for pre-surgery (which is a helluva drop for some girls) but I had been off of my Spiro for two weeks even though for me it is strictly a diuretic for hypertension and my water balance was way off until I had been back on it for two weeks post. Thus, my blood pressure was higher that I was used to, but was still in OK territory. It also did nothing good for my headaches. Another problem a friend of mine (at same hospital) had was from the oxygen nosepiece.