Ethynyl estradiol - What can you tell me? Does it work?

[Dani Davis]

I apologize girls, if this has been brought up before.  I'm pretty new to the site. 

I recently came into some information on this at a web site that is of course, trying to sell it as well.  Has anyone here ever tried it? 

I am non-op and will probably remain that way simply due to finances but the thought of trying something like this out (assuming it would work) sounds fun.  But like with anything, a lot of this stuff is just snake oil preying on the vanity of ladies everywhere.

This is from the site:

Ethynyl estradiol  [EE], is a synthetic derivate of Estradiol [ the natural hormone] and was first made many years ago to overcome the rapid  breakdown of estradiol in the body...etc...side effects:  Your breasts will grow to 80 percent of your mothers cup size within 3 years or more.Your skin will get smoother.Your hair will thin out everywhere but the hair on your head.You will see your hips/butt change slowly into a girly figure.Drop in your libidio.Changes in your moods,you will become more emotional, often less agressive.These changes will take 2 to 4 months to begin and keep continuing as you take the liquid estradiol.
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Feedback?  Thank you, ladies!

[xponentialshift]

I am pretty sure that it is the worst form of estradiol (the kind with all the bad side effects and health risks). More importantly, if it is from a website then it doesn't seem to be regulated by a physician which is very bad (not to mention against ToS)

The beta-17 estradiol that you get through proper HRT channels has all of the same benefits without a lot of the added risk.

If this is what you are interested in, please see a doctor or therapist and look into proper HRT.

[Dani Davis]

Thanks for the quick response, xponentialshift.   I made sure not to mention the site as this was more of a "fact finding" mission...and your information was useful, so hopefully the mods look kindly on me...smile...

[Dani Davis]

This from Wiki:

"The FDA withdrew approval of Estinyl effective June 4, 2004 at the request of Schering, who had discontinued marketing Estinyl."

The web site that's selling that stuff is doing a bad thing it appears.  The full wiki article supported your position above, Xp.

[JohannaJohn]

RUN -- dont walk -- RUN away from this substance ASAP.  Ethynyl estradiol is dangerous in my opinion, and in the opinion of any reputable MD, too.

Many bad and risky side effects -- I would immediately FIRE any MD who tried to "insist" that I put this substance into my body.  And I would find a competent MD who has moved beyond the "Dark Ages" of Ethynyl estradiol

Beta-17-estradiol is a pure form of estogen that is super duper.

Where I live in Latin America, it is hard to obtain beta-17-estradiol, so I have taken estradiol valerate for over 5 weeks and micronized progesterone, with super results I have detailed in the Introductions section.  My nipples and areolas look ready for a baby to nurse on them, I have no more body odor, my hair quality is much better and softer and the hair on my head is growing better again, my facial acne and other acne has almost totally disappeared, I feel GREAT and SO right...!

Estradiol valerate is easy to find in the Latin country where I live, and it is chemically virtually identical to beta 17 estradiol, and basically produces identical results.

So try to get either beta 17 estradiol or estradiol valerate, medical grade, from a pharmaceutical company with the highest reputation for safety and efficacy.

Premarin, which for a long time was the "standard" treatment, is now obsolete also, and I would fire any doctor who tried to prescribe this for me.  Why would I risk Premarin, either, which hurts animals and has some dangerous side effects, too?

It would be stupid for me to agree to take either Premarin or Ethynyl estradiol, when the super duper beta 17 estadiol or estradiol valerate, with minimal to no side effects, are available from any competent MD who knows what the heck he or she is doing.

Happy journey to you!

Hugs,
Johnna.

[Hikari]

With Estradiol Valerate being reasonably cheap, there really isn't much point to give Ethynyl estradiol a second look. It has a track record that is pretty bad for DVT, and other clotting related issues, but at one point seemed fairly popular due to it's low cost. It is still quite widely available worldwide, but I would always take safety over price if there is a choice.

[JohannaJohn]

With Estradiol Valerate being reasonably cheap, there really isn't much point to give Ethynyl estradiol a second look. It has a track record that is pretty bad for DVT, and other clotting related issues, but at one point seemed fairly popular due to it's low cost. It is still quite widely available worldwide, but I would always take safety over price if there is a choice.

Right on and totally correct Hikari!

Johanna

[Dani Davis]

Great information, ladies.  Thank you!

[JohannaJohn]

You're welcome!  Hope this helps you.  I think the folks here have just about fully answered your questions...just speak with your MD about dosages.

You now have the BEST possible answers about WHICH medications.  If you can find a truly competent MD who prescribes either one of these 2 substances (17 beta estradiol OR estradiol valerate) for gender change M to F, you have made the right choices...you just have to get the right doseages, which this site prohibits, but that is okay, speak to a COMPETENT MD, not just any old MD.

It is certainly correct to say estradiol valerate is reasonably priced.  In the Latin country I have lived in for many years, the price in US $ is about $10 for a one-week supply, based on my current dosages.  I consider this to be medium...not cheap, but not expensive.  For me, it is affordable, which is what counts!

Johanna

[peky]

I recently came into some information on this at a web site that is of course, trying to sell it as well.  Has anyone here ever tried it? 

Ethynyl estradiol  [EE], is a synthetic derivate of Estradiol [ the natural hormone] and was first made many years ago to overcome the rapid  breakdown of estradiol in the body...etc...side effects:  Your breasts will grow to 80 percent of your mothers cup size within 3 years or more.Your skin will get smoother.Your hair will thin out everywhere but the hair on your head.You will see your hips/butt change slowly into a girly figure.Drop in your libidio.Changes in your moods,you will become more emotional, often less agressive.These changes will take 2 to 4 months to begin and keep continuing as you take the liquid estradiol.
--------------------
Feedback?  Thank you, ladies!

HRT with Ethinyl estradiol has been associated with a higher incidence of venous thromboembolism (clots in your veins) in cis- or trans-women.

Just plain estrogen (17-B-estradiol), which is the main and natural female estrogen would do you good, of course always under the supervision of a qualified physician.

[traci_k]

Just to reiterate to anyone who may be browsing here. These are powerful substances which cause changes to your body and should not be undertaken without the consultation, prescription and follow-up of a qualified physician,

Best to all,

Traci

[Dani Davis]

Just to reiterate to anyone who may be browsing here. These are powerful substances which cause changes to your body and should not be undertaken without the consultation, prescription and follow-up of a qualified physician,

Best to all,

Traci

Indeed.  In the event that I was not clear, my purpose for the question was as a fact finding mission to find out more information on it and what if any, others experiences have been while using it.

Hopefully, for the purposes of education and discussion these types of questions are allowed here.

[JohannaJohn]

For SURE these are powerful substances.  The PHYSICAL results are totally obvious, and even measurable with photographic evidence which is indisputable.

The mental changes are even more profound...MUCH more than I expected, nearly 6 weeks in.

The mental changes for me are numerous, and astounding, and magnificent, and euphoric.

I feel RIGHT!!!



Johanna.

[Allyda]

For SURE these are powerful substances. The mental changes for me are numerous, and astounding, and magnificent, and euphoric.

I feel RIGHT!!!



Johanna.

All True ^^____^^. For me I felt right on the 3rd day. It was like my body had been starving for this all my life. Finally after many years of misery and despair to feel NORMAL was nothing less than awesome!

Allie

[JoanneB]

Over the decades on several occasions I did ethynil estradiol due to its availability and also that it was not premarin, which had an even worse rep. As a 'Low Dose' regime it did the trick for me providing that much needed brain 'Reset'. And it was LOW. (hard to believe they can make pills that tiny!) Far lower than what the lowest premarin pill.

There are far better and safer ways to go these days. 

[Shantel]

I wrote about my experiences using EE here some time back, got a nasty clot that filled the main artery in my left leg from my foot to the crotch (major DVT). I made it to the ER right away because my leg swelled up twice the size of the other overnight. I was taken off hormones and put on daily doses of Coumadin and weekly blood draws and monitoring for six months, it could have killed me and is a real good reason why we don't self medicate or use that stuff of all that is out there. A lot of folks who have done that are pushing up daisies today.

[JohannaJohn]

Over the decades on several occasions I did ethynil estradiol due to its availability and also that it was not premarin, which had an even worse rep. As a 'Low Dose' regime it did the trick for me providing that much needed brain 'Reset'. And it was LOW. (hard to believe they can make pills that tiny!) Far lower than what the lowest premarin pill.

There are far better and safer ways to go these days.

Joanne B., you are now very fortunate we have moved out of the "Dark Ages" (since about 2008 perhaps??) of the use of Premarin and ethynil estadiol.  An MD precribing these nowadays should be sued for malpractice, since it is now well-established that both have very dangerous, measureable side effects.

So glad, Joanne B., that back in the "Dark Ages" of transgender treatment, you got your "brain reset" and got your mind attuned and feeling right...

Such as I myself have been doing now for 6 weeks, wow it is wonderful.  I am euphoric and amazed at how wonderful I feel.

You were wise to avoid Premarin, which has many dangers.  Plus, it hurts animals.

Long live estradiol valerate (which I use daily), 17 Beta estradiol, and various forms of non-oral administration that use safe and pure forms of our beloved estrogen.

Embraces,
Johanna.

[JoanneB]

The 'Dark Ages' for me go back to 1978 and longer. '78 was around my first 'Experiment' at transition. As you can well imagine there was a lot a buildup to get to that point. For me about 17 or more years of buildup. Another 34 or so after the first to what now seems the right approach for me

[Dani Davis]

According to Wiki, The FDA withdrew approval of EE effective June 4, 2004 at the request of Schering (the manufacturer), who had discontinued marketing it so there shouldn't be any docs prescribing it anymore.

[JohannaJohn]

And any that DO prescribe it, should be SUED for medical malpractice.

And any Websites that sell it, should be SHUT DOWN and prosecuted.

Very dangerous.