So I've been on HRT for about 2 weeks now, and I go in for delestrogen injections every two weeks. I also take Spiro twice a day. For the first two weeks, everything was fine, and I had no negative reaction to the treatment whatsoever. But now, three days after my second injection, I noticed two large bumps on the outer side of my arms, just below both elbows, and one large splotch on my knee. I went to bed thinking it would pass, and woke up with red, itchy welts on my hands, one singular welt next to my eye, and one above my ear. The ones on my arms have gone down considerably, but they've remained for nearly 15 hours now. I noticed them right after I took my Spiro, and honestly, I'm kind of freaking out about it. I really, REALLY don't want it to be the Spiro. I don't even understand how it could be the Spiro, considering I've been taking it for weeks now and nothing like this has happened yet. So, what is this? hives? Something else?