Sometimes I get depressed that I'll never make my own T, but some men my age (and even younger) have low T and need to supplement. I guess the only real difference is the amount. I also think about other people with hormone issues, such as diabetics who need insulin. So when I do get depressed, it's mostly about the whole trans package. For example, I get a lot more depressed about bottom surgery options, and when I add other issues such as not making my own T, the whole mess turns into a great big ball of general trans dysphoria, of which the T is only a small part.
I mostly don't think much about the hormones because the alternative is to NOT inject. For me, that just isn't going to work.
The other stuff--well, I have often felt like a freak, and I do still have issues, but I feel much less that way than I did before I started transition. I actually feel a lot more normal now.
And as for other people . . . I'm not really "out" to people who don't already know about my past, so newcomers take me seriously as a human being, and the old acquaintances . . . take me seriously as a human being. (I'm not counting family because the jury is still out.) It's much better than being called "it" and "that" by absolute strangers.
