When to insert progesterone within hrt

[Newgirl Dani]

Wading through 10 or so pages in the progesterone thread, I decided I needed to ask a more focused question in regards to breast growth.  So.... is it better to allow the body some time for acclimatization to this rather radical hormonal landscape change, or is greater growth achieved if progesterone is working in tandem with estrogen from the beginning.  Today is 90 days using injectable EV and Spiro and I notice rather large ( 1 1/2 in. wide ) and thick breast buds have already formed.  I just need to know if I am short circuiting a possible increase by not adding this to my hrt now, and if later is better, I'm good with that as well.  My choice would be injectable Prometrium.  This is of coarse with my doctors approval.  Now or Wait  Thanks,  Dani

[Jessica Merriman]

Mine was onboard the first visit. Spiro, "E" (inj) and Progesterone (inj). It has worked wonders!

[Newgirl Dani]

Mine was onboard the first visit. Spiro, "E" (inj) and Progesterone (inj). It has worked wonders!

Nice News !!  After reading all the posts over the time period you have been here, could you say that that positive experience you've had would've not been reached if you had started later, meaning EV & P really need each other from the beginning?

[Jessica Merriman]

EV & P really need each other from the beginning?

"E" (Phil Collins) sure needed Spiro and "P" (Genesis) !!!!

I was getting minimal "girl" growth until "P" came along. I think it WAS the difference. Not only the "girls", but "P" stabilized my emotions somewhat so I would say I have had a VERY positive experience with it. My Endo includes "P" in all MtF HRT. 

[Newgirl Dani]

"E" (Phil Collins) sure needed Spiro and "P" (Genesis) !!!!

I was getting minimal "girl" growth until "P" came along. I think it WAS the difference. Not only the "girls", but "P" stabilized my emotions somewhat so I would say I have had a VERY positive experience with it. My Endo includes "P" in all MtF HRT. 

        I suppose that answers that, yay, and.... E & P      I guess that will only leave sorting out the details of how to alternate injection sites, doseage, etc..   Thanks Jessica.  Dani

[Zumbagirl]

I have had this conversation with my endo a few times over the years and his opinion is that it doesn't do much. To be honest what I have found is just give it time and the changes come.

[Newgirl Dani]

I have had this conversation with my endo a few times over the years and his opinion is that it doesn't do much. To be honest what I have found is just give it time and the changes come.

Thanks Zumbagirl, well the other side of the coin shows itself, so I suppose it's just time to see what appears as time goes on.  If anyone has known reasons or links to actual biological reasons why one is better than another, that would be good.  Thanks all 

[KayXo]

My choice would be injectable Prometrium.

The problem with injectable bio-identical progesterone (the same as in Prometrium, oral capsules), is that you need to inject it DAILY as its half-life is VERY short. There are other progestogens that can be injected and last longer like medroxyprogesterone acetate or hydroxyprogesterone caproate. The former has multiple adverse effects and I personally wouldn't go near it. The latter seems to have a better side-effect profile from what I read and is even given to pregnant women to prevent miscarriage.

Mine was onboard the first visit. Spiro, "E" (inj) and Progesterone (inj). It has worked wonders!

Are you injecting progesterone or some other form of progestogen?

I have had this conversation with my endo a few times over the years and his opinion is that it doesn't do much. To be honest what I have found is just give it time and the changes come.

Perhaps for some but for others, it clearly does. One cannot generalize to everyone as the testimonies, including mine in this forum clearly show.

[Madeline182]

My Dr. isn't anti P, but doesn't proactively prescribe it.  I asked him the last time I visited, and he said if I wanted he would, but repeated that he feels it's just an added expense in his opinion.  We'll see... I'm happy with where I'm at given my time line, but by 6mons I wanna see more. If not, I will bring it up again. 

[Jessica Merriman]

I inject my Progesterone only once a month. It allows it to cycle naturally month to month. 

[Madeline182]

*side question*
@Jessica
Is the cost similar to E?

[Jessica Merriman]

*side question*
@Jessica
Is the cost similar to E?

Progesterone with private pay $39.67 after my insurance $2.55
Estradiol Cypionate with private pay $54.28 after my insurance $2.55
BOTH ARE FOR THREE MONTH SUPPLY

It is actually cheaper than Estradiol Cypionate.

[Madeline182]

Progesterone with private pay $39.67 after my insurance $2.55
Estradiol Cypionate with private pay $54.28 after my insurance $2.55
BOTH ARE FOR THREE MONTH SUPPLY

It is actually cheaper than Estradiol Cypionate.

Good to know, ty so much

[KayXo]

I inject my Progesterone only once a month. It allows it to cycle naturally month to month. 

But, if it is bio-identical progesterone, then levels only remain significantly high for 24 to 48 hours AT MOST and that is stretching it. So, you really have two days, at most, each month where progesterone is significant.

Progesterone injectable is usually injected daily in pregnant women who take it to prevent miscarriage, to keep levels steady.

[Jessica Merriman]

Um, it is in a super thick fluid base in deep muscle. It last's long enough!! 

[Lady_Oracle]

My doc started me on P at the same time with estrogen and spiro

[Newgirl Dani]

KayXo:
The problem with injectable bio-identical progesterone (the same as in Prometrium, oral capsules), is that you need to inject it DAILY as its half-life is VERY short.

But, if it is bio-identical progesterone, then levels only remain significantly high for 24 to 48 hours AT MOST and that is stretching it. So, you really have two days, at most, each month where progesterone is significant.

Jessica:
Um, it is in a super thick fluid base in deep muscle. It last's long enough!!

Well after spending some time I did find it stated about (Prometrium) the daily regimen due to half life so that backs up KayXo,  BUT the ratiional alone that it being in deep muscle and in a thick oil base tends to make me wonder.  So I suppose this will go on the back burner for awhile, and that will give me time to examine the oral/liver toxicity relationship.  Thanks for all your input.  Dani

[KayXo]

Um, it is in a super thick fluid base in deep muscle. It last's long enough!! 

Can you find out if it is bio-identical progesterone, hydroxyprogesterone caproate or medroxyprogesterone acetate? Do you have a brand name? Because if it is bio-identical, it would be a total waste of money as it only lasts 1, at most 2 days! Same, but to a lesser degree for hydroxyprogesterone caproate as it tends to last 1-2 weeks at most. And if it is medroxyprogesterone acetate, it seems it could have quite a few adverse effects on the body.

[KayXo]

that will give me time to examine the oral/liver toxicity relationship.

The only instances  I have heard of liver complications with oral progesterone is when high doses are used in women during the second and third trimester of pregnancy due to premature labor. Seems extremely rare. But, as always, do your own research, talk to your doctors.

[Newgirl Dani]

The only instances  I have heard of liver complications with oral progesterone is when high doses are used in women during the second and third trimester of pregnancy due to premature labor. Seems extremely rare. But, as always, do your own research, talk to your doctors.

Good to know, thanks so much.  My next doctor's app is not till late Nov. so I have time to do this right.  Dani